Case studies have been established as an effective teaching tool in a number of disciplines, including science, technology, engineering, and mathematics. They encourage team work, constructive thinking and the application of concepts in the classroom. In this study we investigated the effectiveness of case studies in a 200- level anatomy course that employs the large lecture format of instruction. The results from this study improve our understanding on the usefulness of this approach, and also inform the future utilization of case studies in similar classes.