Monitoring the Stimulated Uncapping Process of Gold-Capped Mesoporous Silica Nanoparticles Augspurger, Ashley Sun, Xiaoxing Trewyn, Brian Fang, Ning Stender, Anthony
dc.contributor.department Ames Laboratory
dc.contributor.department Chemical and Biological Engineering
dc.contributor.department Chemistry 2019-07-15T12:20:25.000 2020-06-29T23:20:54Z 2020-06-29T23:20:54Z 2018-02-05 2018-02-05
dc.description.abstract <p>To establish a new method for tracking the interaction of nanoparticles with chemical cleaving agents, we exploited the optical effects caused by attaching 5–10 nm gold nanoparticles with molecular linkers to large mesoporous silica nanoparticles (MSN). At low levels of gold loading onto MSN, the optical spectra resemble colloidal suspensions of gold. As the gold is removed, by cleaving agents, the MSN revert to the optical spectra typical of bare silica. Time-lapse images of gold-capped MSN stationed in microchannels reveal that the rate of gold release is dependent on the concentration of the cleaving agent. The uncapping process was also monitored successfully for MSN endocytosed by A549 cancer cells, which produce the cleaving agent glutathione. These experiments demonstrate that the optical properties of MSN can be used to directly monitor cleaving kinetics, even in complex cellular settings.</p>
dc.identifier archive/
dc.identifier.articleid 1139
dc.identifier.contextkey 11996371
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ameslab_manuscripts/150
dc.language.iso en
dc.relation.ispartofseries IS-J 9626
dc.source.bitstream archive/|||Fri Jan 14 20:34:21 UTC 2022
dc.source.uri 10.1021/acs.analchem.7b04532
dc.title Monitoring the Stimulated Uncapping Process of Gold-Capped Mesoporous Silica Nanoparticles
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 86545861-382c-4c15-8c52-eb8e9afe6b75
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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