Histopathology of fathead minnow (Pimephales promelas) exposed to hydroxylated fullerenes

dc.contributor.author Jovanović, Boris
dc.contributor.author Jovanovic, Boris
dc.contributor.author Whitley, Elizabeth
dc.contributor.author Palić, Dušan
dc.contributor.department Veterinary Pathology
dc.date 2019-01-15T12:01:48.000
dc.date.accessioned 2020-07-07T05:15:42Z
dc.date.available 2020-07-07T05:15:42Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2014
dc.date.issued 2014-11-01
dc.description.abstract <p>Hydroxylated fullerenes are reported to be very strong antioxidants, acting to quench reactive oxygen species, thus having strong potential for important and widespread applications in innovative therapies for a variety of disease processes. However, their potential for toxicological side effects is still largely controversial and unknown. Effects of hydroxylated fullerenes C60(OH)24 on the fathead minnow (<em>Pimephales promelas</em>) were investigated microscopically after a 72-hour (acute) exposure by intraperitoneal injection of 20 ppm of hydroxylated fullerenes per gram of body mass. Cumulative, semi-quantitative histopathologic evaluation of brain, liver, anterior kidney, posterior kidney, skin, coelom, gills and the vestibuloauditory system revealed significant differences between control and hydroxylated fullerene-treated fish. Fullerene-treated fish had much higher cumulative histopathology scores. Histopathologic changes included loss of cellularity in the interstitium of the kidney, a primary site of haematopoiesis in fish, and loss of intracytoplasmic glycogen in liver. In the coelom, variable numbers of leukocytes, including many macrophages and fewer heterophils and rodlet cells, were admixed with the nanomaterial. These findings raise concern about <em>in vivo</em> administration of hydroxylated fullerenes in experimental drugs and procedures in human medicine, and should be investigated in more detail.</p>
dc.description.comments <p>This article is published as Jovanović, Boris, Elizabeth M. Whitley, and Dušan Palić. "Histopathology of fathead minnow (Pimephales promelas) exposed to hydroxylated fullerenes." <em>Nanotoxicology</em> 8, no. 7 (2014): 755-763. doi: <a href="http://dx.doi.org/10.3109/17435390.2013.828794" target="_blank">10.3109/17435390.2013.828794</a>.</p>
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dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/106/
dc.identifier.articleid 1109
dc.identifier.contextkey 13579723
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/106
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92430
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/106/2014_Jovanovic_HistopathologyFathead.pdf|||Fri Jan 14 18:24:33 UTC 2022
dc.source.uri 10.3109/17435390.2013.828794
dc.subject.disciplines Ecology and Evolutionary Biology
dc.subject.disciplines Terrestrial and Aquatic Ecology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords nanoparticles
dc.subject.keywords liver
dc.subject.keywords kidney
dc.subject.keywords fish
dc.subject.keywords pathology
dc.subject.keywords hydroxylated fullerenes
dc.title Histopathology of fathead minnow (Pimephales promelas) exposed to hydroxylated fullerenes
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 109c096d-f07f-4f3d-a2fe-c5e66eb50449
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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