Mechanics of blast-induced traumatic brain injury in porcine brain tissue

dc.contributor.advisor Sarah A Bentil
dc.contributor.author McCarty, Annastacia
dc.contributor.department Mechanical Engineering
dc.date 2020-06-26T19:59:29.000
dc.date.accessioned 2020-06-30T03:22:14Z
dc.date.available 2020-06-30T03:22:14Z
dc.date.copyright Fri May 01 00:00:00 UTC 2020
dc.date.embargo 2020-06-23
dc.date.issued 2020-01-01
dc.description.abstract <p>Blast-induced traumatic brain injury (bTBI) often results from the detonation of improvised explosive devices (IEDs) in war settings. However, the material properties of the brain and their changes during and after bTBI are currently not well understood. Characterizing brain tissue is challenging due to the inhomogeneous and anisotropic properties of the tissue and the brain's enclosure in the skull. Thus, this research is focused on experimentally quantifying the mechanical properties of brain tissues exposed to a blast wave. Specifically, the effects of swelling from storage solution and blast impact were investigated by exposing whole porcine brains to shock waves generated from an air pistol and allowing whole porcine brains to soak in saline solution. The mechanical properties of the brain tissue were quantified in a stress relaxation experiment in which the tissue was compressed to 80% of its original height at a rate of 5 mm/min, 50 mm/min, or 500 mm/min and then held for two minutes. The work from this thesis will increase understanding of the dynamic mechanical behavior of brain tissue. Results describing the brain's response to shock waves will further knowledge of bTBI mechanisms, which will facilitate the design of effective countermeasures to prevent and protect against blast-induced traumatic brain injury.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/17979/
dc.identifier.articleid 8986
dc.identifier.contextkey 18242586
dc.identifier.doi https://doi.org/10.31274/etd-20200624-158
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/17979
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/32162
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/17979/McCarty_iastate_0097M_18761.pdf|||Fri Jan 14 21:31:56 UTC 2022
dc.subject.keywords Fractional Zener
dc.subject.keywords Shock waves
dc.subject.keywords Traumatic brain injury
dc.subject.keywords Viscoelastic
dc.title Mechanics of blast-induced traumatic brain injury in porcine brain tissue
dc.type article
dc.type.genre thesis
dspace.entity.type Publication
relation.isOrgUnitOfPublication 6d38ab0f-8cc2-4ad3-90b1-67a60c5a6f59
thesis.degree.discipline Mechanical Engineering
thesis.degree.level thesis
thesis.degree.name Master of Science
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