Facile Synthesis of Multivalent Water-Soluble Organic Nanoparticles via “Surface Clicking” of Alkynylated Surfactant Micelles
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Multivalent interactions occur frequently between biological entities.1 When strong binding is not achievable with a single receptor-ligand pair, multivalency, or simultaneous binding between multiple receptors and ligands, becomes an effective strategy to enhance the binding. Significant efforts have been devoted in recent years to synthetic multivalent ligands and their interactions with biological hosts.2 Two of the most widely used scaffolds in multivalency are dendrimers and gold nanoparticles protected with functionalized thiols.
Reprinted (adapted) with permission from Macromolecules 43 (2010): 4020, doi:10.1021/ma100497k. Copyright 2010 American Chemical Society.