Synthetic approaches to huperzine A

dc.contributor.advisor George A. Kraus
dc.contributor.author Vines, Danette
dc.contributor.department Chemistry
dc.date 2018-08-23T17:18:55.000
dc.date.accessioned 2020-06-30T07:05:29Z
dc.date.available 2020-06-30T07:05:29Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 1994
dc.date.issued 1994
dc.description.abstract <p>The natural product huperzine A has been found to possess activity as a nootropic agent. Because of its memory facilitating effects, huperzine A represents a promising drug for the treatment of neurodegenerative diseases, such as Alzheimer's disease. As life expectancy increases, identifying and synthesizing drugs which treat cognitive dysfunction becomes a primary health objective;This study was undertaken to synthesize huperzine A, and to offer a direct route to improved analogs of huperzine A. A bicyclic amino ketone for the synthesis of huperzine A was prepared in six steps. The conjugate addition of metallated alkylpyridines afforded a direct route to pyridones which are common structural subunits in huperzine A.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/rtd/10518/
dc.identifier.articleid 11517
dc.identifier.contextkey 6405262
dc.identifier.doi https://doi.org/10.31274/rtd-180813-9762
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/10518
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/63673
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/rtd/10518/r_9503603.pdf|||Fri Jan 14 18:22:47 UTC 2022
dc.subject.disciplines Medicinal and Pharmaceutical Chemistry
dc.subject.disciplines Medicinal Chemistry and Pharmaceutics
dc.subject.disciplines Medicinal-Pharmaceutical Chemistry
dc.subject.disciplines Organic Chemistry
dc.subject.keywords Chemistry
dc.subject.keywords Organic
dc.subject.keywords Chemistry
dc.subject.keywords Organic chemistry
dc.title Synthetic approaches to huperzine A
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
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