In-vitro experiments on neuronal cells and computer modeling over realistic head models in TMS

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Zhong, Xiaojing
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David C. Jiles
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Electrical and Computer Engineering

The Department of Electrical and Computer Engineering (ECpE) contains two focuses. The focus on Electrical Engineering teaches students in the fields of control systems, electromagnetics and non-destructive evaluation, microelectronics, electric power & energy systems, and the like. The Computer Engineering focus teaches in the fields of software systems, embedded systems, networking, information security, computer architecture, etc.

The Department of Electrical Engineering was formed in 1909 from the division of the Department of Physics and Electrical Engineering. In 1985 its name changed to Department of Electrical Engineering and Computer Engineering. In 1995 it became the Department of Electrical and Computer Engineering.

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  • Department of Electrical Engineering (1909-1985)
  • Department of Electrical Engineering and Computer Engineering (1985-1995)

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Transcranial magnetic stimulation is a neuromodulation technique that can be used as a non-invasive method for treating various neurological disorders. The major principle of TMS is the Faraday’s law stating that time varying magnetic field induces electric field in nearby conductors. More specifically, magnetic field generated by TMS stimulator induces electric current in the conductive brain tissue. Numerous studies have been done to explore the effects of TMS, while the cellular and molecular mechanism underlying is not clear yet. In addition, coil design is also a popular topic as the geometry of coil is able to alter the induced electric field significantly. The work presented in this dissertation discusses the effects of TMS on neuronal cells in vitro and the computational simulations modelling the stimulations delivered to the head. A dopaminergic neuronal cell line is used to examine how TMS affects the proliferation of the cells in vitro. The effects of TMS promoting the proliferation of neuronal cells have been observed under two different cell culture environments. Furthermore, results of thousands of computational simulations were presented in this dissertation. Two coils were placed at three locations to investigate how the electric fields delivered to the cerebellum vary with coil geometry and coil position. Moreover, the intensity and focality of the electric fields generated in the brain by 16 commercial or novel coils were compared. All the coils were placed at the vertex and 9 of them were placed at the dorsolateral prefrontal cortex of the head. Importantly, 50 heterogeneous head models were used in these simulations for each coil and position to explore the role of anatomical variations in TMS.

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Thu Aug 01 00:00:00 UTC 2019