Pharmacokinetics of meloxicam in mature swine after intravenous andoral administration

Date
2015-06-01
Authors
Pairis-Garcia, Monique
Johnson, Anna
Kukanich, Butch
Wulf, Larry
Millman, Suzanne
Stalder, Kenneth
Karriker, Locke
Coetzee, Johann
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Altmetrics
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Animal Science
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Abstract

The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (IV) and oral (PO) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3± 65.68 kg) were administered an IV or PO dose of meloxicam at a target dose of 0.5 mg/kg in a cross-over design. Plasma samples collected up to 48 hours post-administration were analyzed by high pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by non-compartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX) after PO administration was 1070 ng/ml (645-1749 ng/ml). TMAX was recorded at 2.40 hour (0.50-12.00 hours) after PO administration. Half-life (T ½ λz) for IV and PO administration was 6.15 hours (4.39-7.79 hours) and 6.83 hours (5.18-9.63 hours) respectively. The bioavailability (F) for PO administration was 87% (39-351%). The results of the present study suggest that meloxicam is well absorbed after oral administration.

Description

This is a manuscript of an article from Journal of Veterinary Pharmacology and Therapeutics 38 (2015): 265, doi:10.11 11/jvp.12170. Posted with permission.

Keywords
Swine, meloxicam, pharmacokinetics, NSAIDs, oral bioavailability, pig
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