Pharmacokinetics of meloxicam in mature swine after intravenous andoral administration

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dc.contributor.author Karriker, Locke
dc.contributor.author Butters-Johnson, Anna
dc.contributor.author Pairis-Garcia, Monique
dc.contributor.author Johnson, Anna
dc.contributor.author Stalder, Kenneth
dc.contributor.author Kukanich, Butch
dc.contributor.author Wulf, Larry
dc.contributor.author Millman, Suzanne
dc.contributor.author Stalder, Kenneth
dc.contributor.author Karriker, Locke
dc.contributor.author Coetzee, Johann
dc.contributor.department Animal Science
dc.date 2018-02-16T21:22:22.000
dc.date.accessioned 2020-06-29T23:38:16Z
dc.date.available 2020-06-29T23:38:16Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.embargo 2016-06-01
dc.date.issued 2015-06-01
dc.description.abstract <p>The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (IV) and oral (PO) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3± 65.68 kg) were administered an IV or PO dose of meloxicam at a target dose of 0.5 mg/kg in a cross-over design. Plasma samples collected up to 48 hours post-administration were analyzed by high pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by non-compartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX) after PO administration was 1070 ng/ml (645-1749 ng/ml). TMAX was recorded at 2.40 hour (0.50-12.00 hours) after PO administration. Half-life (T ½ λz) for IV and PO administration was 6.15 hours (4.39-7.79 hours) and 6.83 hours (5.18-9.63 hours) respectively. The bioavailability (F) for PO administration was 87% (39-351%). The results of the present study suggest that meloxicam is well absorbed after oral administration.</p>
dc.description.comments <p>This is a manuscript of an article from <em>Journal of Veterinary Pharmacology and Therapeutics</em> 38 (2015): 265, doi:<a href="http://dx.doi.org/10.11%2011/jvp.12170." target="_blank">10.11 11/jvp.12170</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/113/
dc.identifier.articleid 1111
dc.identifier.contextkey 7439743
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/113
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9510
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/113/2015_Butters_PharmacokineticsMeloxicam.pdf|||Fri Jan 14 18:46:58 UTC 2022
dc.source.uri 10.1111/jvp.12170
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Meat Science
dc.subject.disciplines Pharmacy and Pharmaceutical Sciences
dc.subject.keywords Swine
dc.subject.keywords meloxicam
dc.subject.keywords pharmacokinetics
dc.subject.keywords NSAIDs
dc.subject.keywords oral bioavailability
dc.subject.keywords pig
dc.title Pharmacokinetics of meloxicam in mature swine after intravenous andoral administration
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication cdddf686-265a-41eb-9374-c5ff25e5120d
relation.isAuthorOfPublication 9459ddeb-303d-4035-933f-925ec181c7a6
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relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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