Salmonella immunization confers cross protection without confounding pre-harvest serologic monitoring

dc.contributor.author Husa, J.
dc.contributor.author Edler, R.
dc.contributor.author Saltzman, R.
dc.contributor.author Holck, J.
dc.contributor.author Walter, D.
dc.date 2018-08-13T19:12:53.000
dc.date.accessioned 2020-07-02T06:21:20Z
dc.date.available 2020-07-02T06:21:20Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2007
dc.date.issued 2007-01-01
dc.description.abstract <p>Food borne Salmonella Typhimurium is a valid concern for the global pork industry. An attenuated oral swine Salmonella Choleraesuis vaccine has proven to be an effective tool for the pre-harvest reduction of carrier rates for multiple Salmonella spp. Serum antibody assays are available to monitor exposure to wild-type Salmonella infection. This clinical study assessed protection induced by an attenuated oral Salmonella Choleraesuis vaccine against challenge infection with S. Typhimurium in swine. A serologic antibody assay was concurrently evaluated for its ability to differentiate vaccinated pigs from those challenged with Salmonella Typhimurium. Vaccination significantly improved clinical scores, pyrexia, and enteric lesion prevalence, while numerically improving average daily weight gain, and group body weight variation in comparison to unvaccinated/challenged pigs. Vaccination, while protecting pigs against disease, did not generate detectable serum antibodies prior to challenge. No vaccinated animals became seropositive prior to challenge, indicating that conventional ELISA tests could be used in vaccinated pigs to monitor wild-type exposure. Following challenge, there was no detectable difference between vaccinated/challenged and non-vaccinated/challenged animals. All strict control pigs remained serum antibody negative. These findings support the use of this vaccine to protect swine against S. Typhimurium, without confounding pre-harvest Salmonella serologic monitoring programs.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/safepork/2007/allpapers/91/
dc.identifier.articleid 1125
dc.identifier.contextkey 6011030
dc.identifier.doi https://doi.org/10.31274/safepork-180809-77
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath safepork/2007/allpapers/91
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/83916
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/safepork/2007/allpapers/91/2007_HusaJ_SalmonellaImmunizationConfers.pdf|||Sat Jan 15 02:28:09 UTC 2022
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Salmonella immunization confers cross protection without confounding pre-harvest serologic monitoring
dc.type event
dc.type.genre article
dspace.entity.type Publication
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