Quantification of load-dependent changes in the collagen fiber architecture for the strut chordae tendineae-leaflet insertion of porcine atrioventricular heart valves

dc.contributor.author Ross, Colton
dc.contributor.author Hsu, Ming-Chen
dc.contributor.author Hsu, Ming-Chen
dc.contributor.author Baumwart, Ryan
dc.contributor.author Mir, Arshid
dc.contributor.author Burkhart, Harold
dc.contributor.author Holzapfel, Gerhard
dc.contributor.author Wu, Yi
dc.contributor.author Lee, Chung-Hao
dc.contributor.department Mechanical Engineering
dc.date 2020-08-26T12:09:26.000
dc.date.accessioned 2021-02-26T03:15:41Z
dc.date.available 2021-02-26T03:15:41Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.embargo 2021-08-18
dc.date.issued 2020-08-18
dc.description.abstract <p>Atrioventricular heart valves (AHVs) regulate the unidirectional flow of blood through the heart by opening and closing of the leaflets, which are supported in their functions by the chordae tendineae (CT). The leaflets and CT are primarily composed of collagen fibers that act as the load-bearing component of the tissue microstructures. At the CT-leaflet insertion, the collagen fiber architecture is complex, and has been of increasing focus in the previous literature. However, these previous studies have not been able to quantify the load-dependent changes in the tissue’s collagen fiber orientations and alignments. In the present study, we address this gap in knowledge by quantifying the changes in the collagen fiber architecture of the mitral and tricuspid valve’s strut CT-leaflet insertions in response to the applied loads by using a unique approach, which combines polarized spatial frequency domain imaging with uniaxial mechanical testing. Additionally, we characterized these microstructural changes across the <em>same specimen</em> without the need for tissue fixatives. We observed increases in the collagen fiber alignments in the CT-leaflet insertion with increased loading, as described through the degree of optical anisotropy. Furthermore, we used a leaflet-CT-papillary muscle entity method during uniaxial testing to quantify the chordae tendineae mechanics, including the derivation of the Ogden-type constitutive modeling parameters. The results from this study provide a valuable insight into the load-dependent behaviors of the strut CT-leaflet insertion, offering a research avenue to better understand the relationship between tissue mechanics and the microstructure, which will contribute to a deeper understanding of AHV biomechanics.</p>
dc.description.comments <p>This is a post-peer-review, pre-copyedit version of an article published in <em>Biomechanics and Modeling in Mechanobiology</em>. The final authenticated version is available online at DOI: <a href="https://doi.org/10.1007/s10237-020-01379-4" target="_blank">10.1007/s10237-020-01379-4</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/me_pubs/432/
dc.identifier.articleid 1434
dc.identifier.contextkey 19131862
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath me_pubs/432
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/96669
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/me_pubs/432/2020_HsuMingChen_QuantificationLoad.pdf|||Sat Jan 15 00:15:47 UTC 2022
dc.source.uri 10.1007/s10237-020-01379-4
dc.subject.disciplines Biology and Biomimetic Materials
dc.subject.disciplines Biomechanical Engineering
dc.subject.disciplines Medical Biotechnology
dc.subject.keywords Uniaxial mechanical testing
dc.subject.keywords Mitral valve
dc.subject.keywords Tricuspid valve
dc.subject.keywords Constitutive modeling
dc.subject.keywords Polarized spatial frequency domain imaging
dc.subject.keywords Collagen fibers
dc.title Quantification of load-dependent changes in the collagen fiber architecture for the strut chordae tendineae-leaflet insertion of porcine atrioventricular heart valves
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a780f854-309d-4de9-a355-1cebcaf3d6a5
relation.isOrgUnitOfPublication 6d38ab0f-8cc2-4ad3-90b1-67a60c5a6f59
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