Chemically modified polymeric resins for high performance liquid chromatography, solid-phase extraction and organic separation by LC and GC

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dc.contributor.advisor James S. Fritz
dc.contributor.author Sun, Jeffrey
dc.contributor.department Chemistry
dc.date 2018-08-15T11:49:16.000
dc.date.accessioned 2020-06-30T07:01:47Z
dc.date.available 2020-06-30T07:01:47Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 1991
dc.date.issued 1991
dc.description.abstract <p>Polystyrene divinylbenzene (PS/DVB) was chemically modified by the introduction of several hydrophilic functional groups, -COCH[subscript]3, -CH[subscript]2OH, -CH[subscript]2CN, -COCH[subscript]2CH[subscript]2COOH, and one hydrophobic group, -C(CH[subscript]3)[subscript]3. Those functional groups changed the chromatographic behavior of various test compounds on PS/DVB resin. On the hydrophilically modified resins, the capacity factors (k[superscript]') of polar compounds (such as phenol, p-cresol) are increased, while the k[superscript]' of non-polar compounds (such as toluene, cumene) are decreased. The opposite is true for hydrophobically modified resin. The change of k[superscript]' of some compounds resulted in the change of separation factor [alpha] (=k[subscript]2[superscript]'/k[subscript]1[superscript]'). The modified resins offer an additional selectivity parameter for liquid chromatographic separation;The chemically modified polymeric resins (PS/DVB-COCH[subscript]3 and PS/DVB-CH[subscript]2OH) are easily wetted by water. They are excellent for solid-phase extraction (SPE), especially for polar compounds such as phenols. The recoveries of phenols and multihydroxy phenols are overwhelmingly higher than those obtained using commercial SiC[subscript]18. An HPLC system with a minicolumn (4.0 x 4.0 mm) was used to study SPE of various compounds on different stationary phases. The elution efficiency of various solvents was also studied;Sulfonated PS/DVB was used for separation of neutral, basic and weakly basic organic compounds in this research. The basic and weakly basic compounds were separated by an on-line mini-column. The neutral and basic compounds were separated by an off-line mini-column. The sulfonated PS/DVB was also used for separation of amine isomers, showing better separations than a commercial SiC[subscript]18 column;A special, 5 [mu]m non-porous, spherical PS/DVB resin was sulfonated and then packed into the split liner of a capillary gas chromatography to be an amine abstractor. When a sample mixture of basic amines and neutral compounds was injected into the liner, all the basic amines were abstracted quantitatively while all the neutral compounds passed through. The quantitative determination of passed neutral compounds was excellent. A 200-fold excess concentration of a basic compound in the presence of a neutral compound with the same retention time could be abstracted;This special non-porous PS/DVB resin was converted synthetically to a polymeric-mercuric resin, which was used as a selective abstractor of mercaptan compounds in the split liner of capillary GC. Non-mercaptan (both sulfur and non-sulfur) compounds can pass the liner and be quantitatively determined well. The injection temperature was also studied.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/rtd/10072/
dc.identifier.articleid 11071
dc.identifier.contextkey 6385036
dc.identifier.doi https://doi.org/10.31274/rtd-180813-12706
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/10072
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/63178
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/rtd/10072/r_9202393.pdf|||Fri Jan 14 18:12:55 UTC 2022
dc.subject.disciplines Analytical Chemistry
dc.subject.keywords Chemistry
dc.subject.keywords Analytic
dc.subject.keywords Chemistry
dc.title Chemically modified polymeric resins for high performance liquid chromatography, solid-phase extraction and organic separation by LC and GC
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
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