A History of Respiratory Syncytial Viral Vaccine Development… What is next?

dc.contributor.author Salpor, Jessica
dc.contributor.department Biomedical Sciences
dc.contributor.majorProfessor Dr. David Verhoeven
dc.contributor.majorProfessor Dr. Richard Martin
dc.date 2019-09-23T00:19:27.000
dc.date.accessioned 2020-06-30T01:32:18Z
dc.date.available 2020-06-30T01:32:18Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.issued 2018-01-01
dc.description.abstract <p>Although the disease burden of Respiratory Syncytial Virus (RSV) is significant, no human vaccine exists. Historical clinical trial complications in the 1960s and the lack of understanding concerning RSV viral correlates of protection (CoP) and viable in vitro and in vivo models have delayed RSV vaccine development. The World Health Organization (WHO), PATH, the Bill & Melinda Gates Foundation, and the Respiratory Syncytial Virus Network have been dedicated to RSV research efforts. The new vaccine and monoclonal antibody (mAb) candidates, built upon emerging knowledge, show potential for human vaccine viability by 2025 according to the WHO’s Product Development for Vaccines Advisory Committee (Mazur et al., 2018; Shi et al., 2017). This review will focus on challenging aspects of RSV vaccine development and aim to explore current vaccine approaches in clinical development to discuss which show potential for human vaccine viability.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/creativecomponents/100/
dc.identifier.articleid 1091
dc.identifier.contextkey 13360578
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath creativecomponents/100
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/16625
dc.source.bitstream archive/lib.dr.iastate.edu/creativecomponents/100/CCupload.pdf|||Fri Jan 14 18:11:56 UTC 2022
dc.subject.disciplines Virus Diseases
dc.subject.keywords RSV
dc.subject.keywords vaccine
dc.title A History of Respiratory Syncytial Viral Vaccine Development… What is next?
dc.type article
dc.type.genre creativecomponent
dspace.entity.type Publication
relation.isOrgUnitOfPublication 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
thesis.degree.discipline Biomedical Sciences
thesis.degree.level creativecomponent
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