A pilot in silico modeling‐based study of the pathological effects on the biomechanical function of tricuspid valves

dc.contributor.author Laurence, Devin
dc.contributor.author Hsu, Ming-Chen
dc.contributor.author Johnson, Emily
dc.contributor.author Hsu, Ming-Chen
dc.contributor.author Baumwart, Ryan
dc.contributor.author Mir, Arshid
dc.contributor.author Burkhart, Harold
dc.contributor.author Holzapfel, Gerhard
dc.contributor.author Wu, Yi
dc.contributor.author Lee, Chung-Hao
dc.contributor.department Mechanical Engineering
dc.date 2020-05-19T00:46:27.000
dc.date.accessioned 2020-06-30T06:05:37Z
dc.date.available 2020-06-30T06:05:37Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.embargo 2021-05-03
dc.date.issued 2020-05-03
dc.description.abstract <p>Current clinical assessment of functional tricuspid valve regurgitation relies on metrics quantified from medical imaging modalities. Although these clinical methodologies are generally successful, the lack of detailed information about the mechanical environment of the valve presents inherent challenges for assessing tricuspid valve regurgitation. In the present study, we have developed a finite element‐based <em>in silico</em> model of one porcine tricuspid valve (TV) geometry to investigate how various pathological conditions affect the overall biomechanical function of the TV. There were three primary observations from our results. Firstly, the results of the papillary muscle (PM) displacement study scenario indicated more pronounced changes in the TV biomechanical function. Secondly, compared to uniform annulus dilation, nonuniform dilation scenario induced more evident changes in the von Mises stresses (83.8‐125.3 kPa vs 65.1‐84.0 kPa) and the Green‐Lagrange strains (0.52‐0.58 vs 0.47‐0.53) for the three TV leaflets. Finally, results from the pulmonary hypertension study scenario showed opposite trends compared to the PM displacement and annulus dilation scenarios. Furthermore, various chordae rupture scenarios were simulated, and the results showed that the chordae tendineae attached to the TV anterior and septal leaflets may be more critical to proper TV function. This <em>in silico</em> modeling‐based study has provided a deeper insight into the tricuspid valve pathologies that may be useful, with moderate extensions, for guiding clinical decisions.</p>
dc.description.comments <p>This is the peer-reviewed version of the following article: Laurence, Devin W., Emily L. Johnson, Ming‐Chen Hsu, Ryan Baumwart, Arshid Mir, Harold M. Burkhart, Gerhard A. Holzapfel, Yi Wu, and Chung‐Hao Lee. "A pilot in‐silico modeling‐based study of the pathological effects on the biomechanical function of tricuspid valves." <em>International Journal for Numerical Methods in Biomedical Engineering</em> (2020), which has been published in final form at DOI:<a href="https://doi.org/10.1002/cnm.3346" target="_blank">10.1002/cnm.3346</a>.This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/me_pubs/419/
dc.identifier.articleid 1421
dc.identifier.contextkey 17790036
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath me_pubs/419
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/55294
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/me_pubs/419/2020_HsuMingChen_PilotSilico.pdf|||Sat Jan 15 00:11:41 UTC 2022
dc.source.uri 10.1002/cnm.3346
dc.subject.disciplines Biomedical Engineering and Bioengineering
dc.subject.disciplines Systems and Integrative Engineering
dc.subject.keywords chordae tendineae
dc.subject.keywords coaptation height
dc.subject.keywords finite element simulations
dc.subject.keywords functional tricuspid regurgitation
dc.subject.keywords tenting area
dc.subject.keywords tenting height
dc.title A pilot in silico modeling‐based study of the pathological effects on the biomechanical function of tricuspid valves
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a780f854-309d-4de9-a355-1cebcaf3d6a5
relation.isOrgUnitOfPublication 6d38ab0f-8cc2-4ad3-90b1-67a60c5a6f59
File
Original bundle
Now showing 1 - 1 of 1
Name:
2020_HsuMingChen_PilotSilico.pdf
Size:
1.9 MB
Format:
Adobe Portable Document Format
Description:
Collections