Maize Inbreds Exhibit High Levels of Copy Number Variation (CNV) and Presence/Absence Variation (PAV) in Genome Content Springer, Nathan Nettleton, Dan Ying, Kai Fu, Yan Ji, Tieming Yeh, Cheng-Ting Jia, Yi Wu, Wei Richmond, Todd Kitzman, Jacob Rosenbaum, Heidi Iniguez, A. Leonardo Barbazuk, W. Brad Jeddeloh, Jeffrey Nettleton, Daniel Schnable, Patrick
dc.contributor.department Agronomy
dc.contributor.department Statistics
dc.contributor.department Genetics, Development and Cell Biology
dc.contributor.department Bioinformatics and Computational Biology
dc.contributor.department Genetics
dc.contributor.department Plant Biology 2018-02-17T08:42:51.000 2020-06-29T23:07:00Z 2020-06-29T23:07:00Z 2009-11-20
dc.description.abstract <p>Following the domestication of maize over the past ∼10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation, including copy number variation (CNV) and presence/absence variation (PAV), which are thought to contribute to the extraordinary phenotypic diversity and plasticity of this important crop, have not been elucidated. Whole-genome, array-based, comparative genomic hybridization (CGH) revealed a level of structural diversity between the inbred lines B73 and Mo17 that is unprecedented among higher eukaryotes. A detailed analysis of altered segments of DNA conservatively estimates that there are several hundred CNV sequences among the two genotypes, as well as several thousand PAV sequences that are present in B73 but not Mo17. Haplotype-specific PAVs contain hundreds of single-copy, expressed genes that may contribute to heterosis and to the extraordinary phenotypic diversity of this important crop.</p>
dc.description.comments <p>This article is from PLoS Genet 5(11): e1000734. doi:<a href="" target="_blank">10.1371/journal.pgen.1000734</a>. Posted with permission.</p>
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dc.identifier archive/
dc.identifier.articleid 1073
dc.identifier.contextkey 7945605
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath agron_pubs/73
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 01:45:53 UTC 2022
dc.source.uri 10.1371/journal.pgen.1000734
dc.subject.disciplines Agricultural Science
dc.subject.disciplines Agriculture
dc.subject.disciplines Agronomy and Crop Sciences
dc.subject.disciplines Bioinformatics
dc.subject.disciplines Computational Biology
dc.subject.disciplines Plant Breeding and Genetics
dc.subject.keywords Plant genomics
dc.subject.keywords Maize
dc.subject.keywords Sequence alignment
dc.subject.keywords Genomic libraries
dc.subject.keywords Genomic signal processing
dc.subject.keywords Probe hybridization
dc.subject.keywords Haplotypes
dc.subject.keywords Inbred strains
dc.title Maize Inbreds Exhibit High Levels of Copy Number Variation (CNV) and Presence/Absence Variation (PAV) in Genome Content
dc.type article
dc.type.genre article
dspace.entity.type Publication
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