Immunologic and virologic findings in a bull chronically infected with noncytopathic bovine viral diarrhea virus

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Bolin, S. R.
Roth, J. A.
Uhlenhopp, E. K.
Pohlenz, J. F.
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Veterinary Pathology
The Department of Veterinary Pathology Labs provides high quality diagnostic service to veterinarians in Iowa and throughout the Midwest. Packages may be delivered through the postage service or by dropping samples off at our lab in Iowa State University’s College of Veterinary Medicine campus.
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Veterinary Clinical Sciences
The mission of the Veterinary Clinical Sciences Department and the Veterinary Medical Center is to be strong academically, to provide outstanding services, and to conduct research in the multiple areas of Veterinary Clinical Sciences. Our goals are to teach students in the multiple disciplines of Veterinary Clinical Sciences, to provide excellent veterinary services to clients, and to generate and disseminate new knowledge in the areas of Veterinary Clinical Sciences. Our objectives are to provide a curriculum in the various aspects of Veterinary Clinical Sciences which ensures students acquire the skills and knowledge to be successful in their chosen careers. We also strive to maintain a caseload of sufficient size and diversity which insures a broad clinical experience for students, residents, and faculty. In addition, we aim to provide clinical veterinary services of the highest standards to animal owners and to referring veterinarians. And finally, we strive to provide an environment and opportunities which foster and encourage the generation and dissemination of new knowledge in many of the disciplines of Veterinary Clinical Sciences.
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Veterinary Microbiology and Preventive Medicine
Our faculty promote the understanding of causes of infectious disease in animals and the mechanisms by which diseases develop at the organismal, cellular and molecular levels. Veterinary microbiology also includes research on the interaction of pathogenic and symbiotic microbes with their hosts and the host response to infection.
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Veterinary PathologyVeterinary Clinical SciencesVeterinary Microbiology and Preventive Medicine

In February 1985, a 2-year-old bull with inappetence and weight loss of 1-week duration was examined by the field services staff of the Iowa State University College of Veterinary Medicine. The bull had a normal rectal temperature, decreased rumen activity, and loose feces and walked with a stiff gait. The hemogram was normal for hemoglobin concentration, PCV, and total plasma protein concentration, but the bull had a leukopenia which was primarily attributable to an absolute lymphopenia. Treatment consisted of antimicrobial drugs, an antidiarrheal medication, and a nonsteroidal anti-inflammatory and analgesic drug. After 3 weeks without improvement, the bull was admitted to the Iowa State University Large Animal Hospital.


This article is published as Bolin, S.R., J.A. Roth, E.K. Uhlenhopp, and J.F. Pohlenz. 1987. Immunologic and virologic findings from a case of chronic bovine viral diarrhea. J Am Vet Med Assoc, 190:1015-1017.