Adaptive system identification for estimating future glucose concentrations and hypoglycemia alarms

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Eren-Oruklu, Meriyan
Cinar, Ali
Quinn, Lauretta
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Elsevier Ltd.
Rollins, Derrick K
University Professor Emeritus
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Chemical and Biological Engineering

The function of the Department of Chemical and Biological Engineering has been to prepare students for the study and application of chemistry in industry. This focus has included preparation for employment in various industries as well as the development, design, and operation of equipment and processes within industry.Through the CBE Department, Iowa State University is nationally recognized for its initiatives in bioinformatics, biomaterials, bioproducts, metabolic/tissue engineering, multiphase computational fluid dynamics, advanced polymeric materials and nanostructured materials.

The Department of Chemical Engineering was founded in 1913 under the Department of Physics and Illuminating Engineering. From 1915 to 1931 it was jointly administered by the Divisions of Industrial Science and Engineering, and from 1931 onward it has been under the Division/College of Engineering. In 1928 it merged with Mining Engineering, and from 1973–1979 it merged with Nuclear Engineering. It became Chemical and Biological Engineering in 2005.

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1913 - present

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  • Department of Chemical Engineering (1913–1928)
  • Department of Chemical and Mining Engineering (1928–1957)
  • Department of Chemical Engineering (1957–1973, 1979–2005)
    • Department of Chemical and Biological Engineering (2005–present)

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The Department of Statistics seeks to teach students in the theory and methodology of statistics and statistical analysis, preparing its students for entry-level work in business, industry, commerce, government, or academia.

The Department of Statistics was formed in 1948, emerging from the functions performed at the Statistics Laboratory. Originally included in the College of Sciences and Humanities, in 1971 it became co-directed with the College of Agriculture.

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Many patients with diabetes experience high variability in glucose concentrations that includes prolonged hyperglycemia or hypoglycemia. Models predicting a subject’s future glucose concentrations can be used for preventing such conditions by providing early alarms. This paper presents a time-series model that captures dynamical changes in the glucose metabolism. Adaptive system identification is proposed to estimate model parameters which enable the adaptation of the model to inter-/intra-subject variation and glycemic disturbances. It consists of on-line parameter identification using the weighted recursive least squares method and a change detection strategy that monitors variation in model parameters. Univariate models developed from a subject’s continuous glucose measurements are compared to multivariate models that are enhanced with continuous metabolic, physical activity and lifestyle information from a multi-sensor body monitor. A real life application for the proposed algorithm is demonstrated on early (30 min in advance) hypoglycemia detection.
This is a manuscript of an article published as Eren-Oruklu, Meriyan, Ali Cinar, Derrick K. Rollins, and Lauretta Quinn. "Adaptive system identification for estimating future glucose concentrations and hypoglycemia alarms." Automatica 48, no. 8 (2012): 1892-1897. DOI: 10.1016/j.automatica.2012.05.076. Copyright 2012 Elsevier Ltd. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). Posted with permission.