Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice

dc.contributor.author Narasimhan, Balaji
dc.contributor.author Ross, Kathleen
dc.contributor.author Senapati, Sujata
dc.contributor.author Alley, Jessica
dc.contributor.author Darling, Ross
dc.contributor.author Goodman, Jonathan
dc.contributor.author Jefferson, Matthew
dc.contributor.author Uz, Metin
dc.contributor.author Mallapragada, Surya
dc.contributor.author Guo, Baoqing
dc.contributor.author Yoon, Kyoung-Jin
dc.contributor.author Verhoeven, David
dc.contributor.author Kohut, Marian
dc.contributor.author Mallapragada, Surya
dc.contributor.author Wannemuehler, Michael
dc.contributor.author Narasimhan, Balaji
dc.contributor.department Ames Laboratory
dc.contributor.department Neuroscience
dc.contributor.department Kinesiology
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.contributor.department Materials Science and Engineering
dc.contributor.department Chemical and Biological Engineering
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.contributor.department Ames Laboratory
dc.date 2019-02-02T02:43:45.000
dc.date.accessioned 2020-06-30T01:09:54Z
dc.date.available 2020-06-30T01:09:54Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.embargo 2020-01-09
dc.date.issued 2019-01-01
dc.description.abstract <p>Immunosenescence poses a formidable challenge in designing effective influenza vaccines for aging populations. While approved vaccines against influenza viruses exist, their efficacy in older adults is significantly decreased due to the diminished capabilities of innate and adaptive immune responses. In this work, the ability of a combination nanovaccine containing both recombinant hemagglutinin and nucleoprotein to provide protection against seasonal influenza virus infection was examined in young and aged mice. Vaccine formulations combining two nanoadjuvants, polyanhydride nanoparticles and pentablock copolymer micelles, were shown to enhance protection against challenge compared to each adjuvant alone in young mice. Nanoparticles were shown to enhance in vitro activation of dendritic cells isolated from aged mice, while both nanoadjuvants did not induce proinflammatory cytokine secretion which may be detrimental in aged individuals. In addition, the combination nanovaccine platform was shown to induce demonstrable antibody titers in both young and aged mice that correlated with the maintenance of body weight post-challenge. Collectively, these data demonstrate that the combination nanovaccine platform is a promising technology for influenza vaccines for older adults.</p>
dc.description.comments <p>This is a manuscript of an article published as Ross, Kathleen A., Sujata Senapati, Jessica R. Alley, Ross J. Darling, Jonathan Goodman, Matthew Jefferson, Metin Uz, Baoqing Guo , Kyoung-Jin Yoon , David E Verhoeven , Marian L. Kohut , Surya K. Mallapragada, Michael J. Wannemuehler and Balaji Narasimhan. "Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice." <em>Biomaterials Science</em> (2019). doi: <a href="http://dx.doi.org/10.1039/C8BM01443D" target="_blank">10.1039/C8BM01443D</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/cbe_pubs/355/
dc.identifier.articleid 1357
dc.identifier.contextkey 13634554
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath cbe_pubs/355
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/13456
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/cbe_pubs/355/2019_MallapragadaSurya_SingleDose.pdf|||Fri Jan 14 23:45:16 UTC 2022
dc.source.uri 10.1039/C8BM01443D
dc.subject.disciplines Biomaterials
dc.subject.disciplines Kinesiology
dc.subject.disciplines Nanoscience and Nanotechnology
dc.subject.disciplines Pharmacology
dc.subject.disciplines Veterinary Medicine
dc.title Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice
dc.type article
dc.type.genre article
dspace.entity.type Publication
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