Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics

dc.contributor.author Martinez, Marilyn
dc.contributor.author Mochel, Jonathan
dc.contributor.author Neuhoff, Sibylle
dc.contributor.author Pade, Devendra
dc.contributor.department Biomedical Sciences
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2021-05-10T20:06:58.000
dc.date.accessioned 2021-08-14T02:24:12Z
dc.date.available 2021-08-14T02:24:12Z
dc.date.issued 2021-04-27
dc.description.abstract <p>This review is a summary of factors affecting the drug pharmacokinetics (PK) of dogs <em>versus</em> humans. Identifying these interspecies differences can facilitate canine-human PK extrapolations while providing mechanistic insights into species-specific drug <em>in vivo</em> behavior. Such a cross-cutting perspective can be particularly useful when developing therapeutics targeting diseases shared between the two species such as cancer, diabetes, cognitive dysfunction, and inflammatory bowel disease. Furthermore, recognizing these differences also supports a reverse PK extrapolations from humans to dogs. To appreciate the canine-human differences that can affect drug absorption, distribution, metabolism, and elimination, this review provides a comparison of the physiology, drug transporter/enzyme location, abundance, activity, and specificity between dogs and humans. Supplemental material provides an in-depth discussion of certain topics, offering additional critical points to consider. Based upon an assessment of available state-of-the-art information, data gaps were identified. The hope is that this manuscript will encourage the research needed to support an understanding of similarities and differences in human <em>versus</em> canine drug PK.</p>
dc.description.comments <p>This article is published as Martinez, Marilyn N., Jonathan P. Mochel, Sibylle Neuhoff, and Devendra Pade. "Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics." <em>The AAPS Journal</em> 23 (2021): 59. DOI: <a href="https://doi.org/10.1208/s12248-021-00590-0" target="_blank">10.1208/s12248-021-00590-0</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/bms_pubs/97/
dc.identifier.articleid 1094
dc.identifier.contextkey 22810098
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bms_pubs/97
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/8zn74Wow
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/bms_pubs/97/2021_MochelJonathan__ComparisonCanine.pdf|||Sat Jan 15 02:36:48 UTC 2022
dc.source.uri 10.1208/s12248-021-00590-0
dc.subject.disciplines Medicinal and Pharmaceutical Chemistry
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Toxicology and Pharmacology
dc.subject.keywords ADME
dc.subject.keywords canine-human interspecies extrapolation
dc.subject.keywords metabolism
dc.subject.keywords scaling factors
dc.subject.keywords transporters
dc.title Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a34180b7-6b71-4b6f-a08d-5a53c5122d9b
relation.isOrgUnitOfPublication 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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