Enantioselective epoxidation catalyzed by manganese-substituted human carbonic anhydrase
dc.contributor.advisor | Levi M. Stanley | |
dc.contributor.author | Weerasekara, Sagarika | |
dc.contributor.department | Chemistry | |
dc.date | 2018-08-12T02:40:34.000 | |
dc.date.accessioned | 2020-06-30T02:59:59Z | |
dc.date.available | 2020-06-30T02:59:59Z | |
dc.date.copyright | Thu Jan 01 00:00:00 UTC 2015 | |
dc.date.embargo | 2001-01-01 | |
dc.date.issued | 2015-01-01 | |
dc.description.abstract | <p>Artificial metalloenzymes are an important class of hybrid catalysts for enantioselective, regioselective and chemoselective organic transformations. Despite several limitations associated with this type of hybrid catalysts system and their limited development relative to small molecule catalysts, significant advances have been achieved over the past few decades. This thesis describes the background, applicability of such hybrid catalysts, anchoring strategies and methods involved in the improvement of catalytic activities of artificial metalloenzymes. The generation of a thermostable human carbonic anhydrase mutant, activity determination, generation of an artificial metalloenzyme (manganese-substituted human carbonic anhydrase) and its use as a catalyst for enantioselective epoxidation of olefins is also described.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/etd/14900/ | |
dc.identifier.articleid | 5907 | |
dc.identifier.contextkey | 8436165 | |
dc.identifier.doi | https://doi.org/10.31274/etd-180810-4498 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | etd/14900 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/29084 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/etd/14900/Weerasekara_iastate_0097M_15347.pdf|||Fri Jan 14 20:28:34 UTC 2022 | |
dc.subject.disciplines | Chemistry | |
dc.subject.keywords | Organic Chemistry | |
dc.title | Enantioselective epoxidation catalyzed by manganese-substituted human carbonic anhydrase | |
dc.type | article | |
dc.type.genre | thesis | |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11 | |
thesis.degree.discipline | Organic Chemistry | |
thesis.degree.level | thesis | |
thesis.degree.name | Master of Science |
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