Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

dc.contributor.author Mochel, Jonathan
dc.contributor.author Jergens, Albert
dc.contributor.author Kingsbury, Dawn
dc.contributor.author Mochel, Jonathan
dc.contributor.author Kim, Hyun Jung
dc.contributor.author Martín, Martín
dc.contributor.author Allenspach, Karin
dc.contributor.department Biomedical Sciences
dc.contributor.department Veterinary Clinical Sciences
dc.date 2018-02-19T06:59:25.000
dc.date.accessioned 2020-06-30T00:53:23Z
dc.date.available 2020-06-30T00:53:23Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2017
dc.date.issued 2018-01-01
dc.description.abstract <p>Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and metabolism. They are, therefore, particularly relevant to study the gastrointestinal (GI) absorption of oral medications. In addition, organoids have the potential to serve as a robust preclinical model for demonstrating the effectiveness of new drugs more rapidly, with more certainty, and at lower costs compared with live animal studies. Importantly, because they are derived from individuals with different genotypes, environmental risk factors and drug sensitivity profiles, organoids are a highly relevant screening system for personalized therapy in both human and veterinary medicine. Lastly, and in the context of patient-specific congenital diseases, orthotopic transplantation of engineered organoids could repair and/or replace damaged epithelial tissues reported in various GI diseases, such as inflammatory bowel disease, cystic fibrosis, and tuft enteropathy. Ongoing translational research on organoids derived from dogs with naturally occurring digestive disorders has the potential to improve the predictability of preclinical models used for optimizing the therapeutic management of severe chronic enteropathies in human patients.</p>
dc.description.comments <p>This article is published as Mochel, Jonathan P., Albert E. Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G. Martín, and Karin Allenspach. "Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research." <em>The AAPS journal</em> 20, no. 1 (2018): 17. doi: <a href="http://dx.doi.org/10.1208/s12248-017-0178-1" target="_blank">10.1208/s12248-017-0178-1</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/bms_pubs/47/
dc.identifier.articleid 1047
dc.identifier.contextkey 11317871
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bms_pubs/47
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/11172
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/bms_pubs/47/2017_Mochel_IntestinalStem.pdf|||Sat Jan 15 00:25:02 UTC 2022
dc.source.uri 10.1208/s12248-017-0178-1
dc.subject.disciplines Medicine and Health Sciences
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Toxicology and Pharmacology
dc.subject.keywords dog
dc.subject.keywords enteropathies
dc.subject.keywords organoid
dc.subject.keywords precision medicine
dc.subject.keywords transplantation
dc.title Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research
dc.type article
dc.type.genre article
dspace.entity.type Publication
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