Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis

dc.contributor.author Peters, Reuben
dc.contributor.author Peters, Reuben J.
dc.contributor.department Biochemistry, Biophysics and Molecular Biology
dc.date.accessioned 2022-03-02T14:08:59Z
dc.date.available 2022-03-02T14:08:59Z
dc.date.issued 2022-04
dc.description.abstract Tanshinones are the bioactive diterpenoid constituents of the traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), and are examples of the phenolic abietanes widely found within the Lamiaceae plant family. Due to the significant interest in these labdane-related diterpenoid natural products, their biosynthesis has been intensively investigated. In addition to providing the basis for metabolic engineering efforts, this work further yielded pioneering insights into labdane-related diterpenoid biosynthesis in the Lamiaceae more broadly. This includes stereochemical foreshadowing of aromatization, with novel protein domain loss in the relevant diterpene synthase, as well as broader phylogenetic conservation of the relevant enzymes. Beyond such summary of more widespread metabolism, formation of the furan ring that characterizes the tanshinones also has been recently elucidated. Nevertheless, the biocatalysts for the pair of demethylations remain unknown, and the intriguing potential connection of these reactions to the further aromatization observed in the tanshinones are speculated upon here.
dc.description.comments This is a manuscript of an article published as Wang, Zhibiao, and Reuben J. Peters. "Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis." Current Opinion in Plant Biology 66 (2022): 102189. doi:10.1016/j.pbi.2022.102189. Posted with permission. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/kv7k6P4v
dc.language.iso en
dc.publisher © 2022 Elsevier Ltd.
dc.source.uri https://doi.org/10.1016/j.pbi.2022.102189 *
dc.subject Terpene synthases
dc.subject Cytochromes P450
dc.subject 2-oxoglutarate dependent dioxygenases
dc.subject Short-chain alcohol dehydrogenases/reductases
dc.title Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis
dc.type Article
dspace.entity.type Publication
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