The effects of nicotinamide riboside on postprandial oxidative stress and vascular function

dc.contributor.advisor Rudy J Valentine
dc.contributor.author Schiff, Isaac
dc.contributor.department Food Science and Human Nutrition
dc.date 2020-09-23T19:13:11.000
dc.date.accessioned 2021-02-25T21:36:20Z
dc.date.available 2021-02-25T21:36:20Z
dc.date.copyright Sat Aug 01 00:00:00 UTC 2020
dc.date.embargo 2021-02-28
dc.date.issued 2020-01-01
dc.description.abstract <p>High-fat meal (HFM) consumption increases oxidative stress in humans. The metabolic cofactor nicotinamide adenine dinucleotide (NAD+), has been identified as a key regulator of oxidative stress. Older individuals suffer from low NAD+ levels and experience age-related increases in oxidative stress. Nicotinamide Riboside (NR), a newly discovered NAD+ precursor has demonstrated the ability to raise NAD+ in older adults. Nicotinic Acid (NA), another NAD+ precursor is established as one of the oldest anti-atherogenic supplements that improves vascular function. Similarities between NR and NA indicate NR may have potential vascular benefits yet to be discovered. We hypothesized that one week of NR supplementation would reduce postprandial oxidative stress and improve vascular function following consumption of a HFM (1050 kcal, 72g fat) in old and young participants. We performed a double-blind, placebo-controlled crossover study with 16 participants, divided into young (n=13) and old (n=3) groups, assessing one week of 250mg 2x/day NR on a lipid peroxidation indicator of oxidative stress. Microvascular function was determined with blood flow measurements of post occlusive reactive hyperemia (PORH), analyzed using laser speckle contrast imaging (LSCI). NR supplementation did not significantly affect levels of postprandial lipid peroxidation indicators of oxidative stress (MDA). No differences in postprandial PORH measures of microvascular function were identified for treatment, time and interaction. Plasma MDA, glucose, and triglycerides all increased postprandially with significantly higher levels reported in the old group compared to young (p<0.001, p=0.04, p<0.001, respectively). One week of NR supplementation was well tolerated in all participants but had no effect on postprandial oxidative stress and microvascular function.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/18220/
dc.identifier.articleid 9227
dc.identifier.contextkey 19236806
dc.identifier.doi https://doi.org/10.31274/etd-20200902-139
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/18220
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/94372
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/18220/Schiff_iastate_0097M_19019.pdf|||Fri Jan 14 21:38:48 UTC 2022
dc.subject.keywords Niacin
dc.subject.keywords Nicotinamide Riboside
dc.subject.keywords Post Occlusive Reactive Hyperemia
dc.title The effects of nicotinamide riboside on postprandial oxidative stress and vascular function
dc.type article
dc.type.genre thesis
dspace.entity.type Publication
relation.isOrgUnitOfPublication 4b6428c6-1fda-4a40-b375-456d49d2fb80
thesis.degree.discipline Diet and Exercise
thesis.degree.level thesis
thesis.degree.name Master of Science
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