The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary Infection

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dc.contributor.author Brogden, Kim
dc.contributor.author Kalfa, V.
dc.contributor.author Ackermann, Mark
dc.contributor.author Ackermann, Mark
dc.contributor.author Palmquist, D.
dc.contributor.author McCray, Paul
dc.contributor.author Tack, B.
dc.contributor.department Veterinary Pathology
dc.date 2018-02-13T06:20:57.000
dc.date.accessioned 2020-07-07T05:15:48Z
dc.date.available 2020-07-07T05:15:48Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2001
dc.date.embargo 2013-02-25
dc.date.issued 2001-01-01
dc.description.abstract <p>Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP18<sub>31</sub>, CAP18<sub>28</sub>, CAP18<sub>22</sub>, and CAP18<sub>21a</sub> were the most active, with MICs as low as 0.6 μg/ml. Other cathelicidins were less active. In lambs with pneumonia, 0.5 mg of SMAP29 reduced the concentration of bacteria in both bronchoalveolar lavage fluid and consolidated pulmonary tissues. Hence, the antimicrobial activity of SMAP29 suggests that it has applications in the treatment of respiratory tract infections.</p>
dc.description.comments <p>This article is from <em>Antimicrobial Agents and Chemotherapy </em>45, no. 1 (January 2001): 331–334, doi:<a href="http://dx.doi.org/10.1128/AAC.45.1.331-334.2001" target="_blank">10.1128/AAC.45.1.331-334.2001</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/25/
dc.identifier.articleid 1017
dc.identifier.contextkey 3784294
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/25
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92448
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/25/2001_Brogden_OvineCathelicidinSMAP29.pdf|||Fri Jan 14 22:55:26 UTC 2022
dc.source.uri 10.1128/​AAC.45.1.331-334.2001
dc.subject.disciplines Pediatrics
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary Infection
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 86c1ed73-b60d-48ce-8f35-449bc320a693
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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