Live Attenuated Influenza A Virus Vaccine Protects against A(H1N1)pdm09 Heterologous Challenge without Vaccine Associated Enhanced Respiratory Disease

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dc.contributor.author Gauger, Phillip
dc.contributor.author Loving, Crystal
dc.contributor.author Roth, James
dc.contributor.author Khurana, Surender
dc.contributor.author Lorusso, Alessio
dc.contributor.author Perez, Daniel
dc.contributor.author Kehrli, Marcus
dc.contributor.author Roth, James
dc.contributor.author Golding, Hana
dc.contributor.author Vincent, Amy
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T04:47:25.000
dc.date.accessioned 2020-07-07T05:15:25Z
dc.date.available 2020-07-07T05:15:25Z
dc.date.issued 2014-12-01
dc.description.abstract <p>Live-attenuated influenza virus (LAIV) vaccines may provide cross-protection against contemporary influenza A virus (IAV) in swine. Conversely, whole inactivated virus (WIV) vaccines have the potential risk of vaccine-associated enhanced respiratory disease (VAERD) when challenged with IAV of substantial antigenic drift. A temperature sensitive, intranasal H1N2 LAIV was compared to wild type exposure (WT) and an intramuscular WIV vaccine in a model shown to induce VAERD. WIV vaccinated swine challenged with pandemic A/H1N1 (H1N1pdm09) were not protected from infection and demonstrated severe respiratory disease consistent with VAERD. Lung lesions were mild and challenge virus was not detected in the respiratory tract of LAIV vaccinates. High levels of post-vaccination IgG serum antibodies targeting the H1N1pdm09 HA2 stalk domain were exclusively detected in the WIV group and associated with increased H1N1pdm09 virus infectivity in MDCK cells. In contrast, infection-enhancing antibodies were not detected in the serum of LAIV vaccinates and VAERD was not observed.</p>
dc.description.comments <p>This article is from <em>Virology</em> 471-473 (2014): 93, doi:<a href="http://dx.doi.org/10.1016/j.virol.2014.10.003" id="x-ddDoi" target="_blank">10.1016/j.virol.2014.10.003</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/75/
dc.identifier.articleid 1084
dc.identifier.contextkey 7793800
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/75
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92383
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/75/2014_Roth_LiveAttenuated.pdf|||Sat Jan 15 01:49:11 UTC 2022
dc.source.uri 10.1016/j.virol.2014.10.003
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords Swine
dc.subject.keywords Influenza A
dc.subject.keywords Pandemic H1N1
dc.subject.keywords Live attenuated influenza virus
dc.subject.keywords Whole inactivated virus
dc.subject.keywords Enhanced pneumonia
dc.title Live Attenuated Influenza A Virus Vaccine Protects against A(H1N1)pdm09 Heterologous Challenge without Vaccine Associated Enhanced Respiratory Disease
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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