Development of efficacious replicon particle vaccines for swine influenza virus

dc.contributor.advisor Louisa Tabatabai
dc.contributor.advisor Jeffrey Zimmerman Vander Veen, Ryan
dc.contributor.department Veterinary Microbiology and Preventive Medicine 2018-08-11T16:59:48.000 2020-06-30T02:28:01Z 2020-06-30T02:28:01Z Sat Jan 01 00:00:00 UTC 2011 2013-06-05 2011-01-01
dc.description.abstract <p>Swine influenza virus is endemic in the United States swine population. Vaccination of swine against influenza is the most reliable method for decreasing influenza infection in swine. Therefore, new swine influenza vaccines that can be produced rapidly to respond to emerging subtypes or clusters are needed. In these studies the alphavirus replicon technology was utilized to produce several different swine influenza vaccine candidates. A recombinant hemagglutinin (HA) protein vaccine protected against homologous pandemic H1N1 challenge at several different doses. Replicon particle (RP) vaccines expressing the HA proteins of pandemic H1N1 and an H3N2 virus also protected against subsequent homologous challenge. Further, an RP vaccine expressing the conserved nucleoprotein (NP) of an H3N2 provided a level of protection against heterologous pandemic H1N1 challenge. In addition to evaluating the efficacy, these studies also demonstrate the safety of swine influenza RP vaccines. The HA RP vaccine was not shed or spread from vaccinated animals and no reversion to virulence was detected following vaccination of both host and non-host species. Thus, these studies demonstrate that swine influenza RP vaccines are both safe and efficacious.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1408
dc.identifier.contextkey 2798782
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/10373
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 18:19:34 UTC 2022
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords alphavirus
dc.subject.keywords hemagglutinin
dc.subject.keywords influenza
dc.subject.keywords replicon particle
dc.subject.keywords swine
dc.subject.keywords vaccine
dc.title Development of efficacious replicon particle vaccines for swine influenza virus
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83 dissertation Doctor of Philosophy
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