Formation of novel hairpin structures by telemeric C-strand oligonucleotides
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Telomeres are specialized structures at the ends of chromosomes that are required for long term chromosome stability and replication of the chromosomal terminus. Telomeric DNA consists of simple repetitive sequences with one strand G-rich relative to the other, C-rich, strand. Evolutionary conservation of this feature of telomeric repeat sequences suggests that they have specific structural characteristics involved in telomere function. Absorbance thermal denaturation, chemical modification and non-denaturing gel electrophoretic analyses showed that telomeric C-strand oligonucIeotides form stable non-Watson-Crick hairpin structures containing C.C + base pairs.Formation of such hairpins may facilitate previously reported G-strand exclusive interactions.
This article is from Nucleic Acids Research 20 (1992): 507, doi: 10.1093/nar/20.3.507. Posted with permission.