Formation of novel hairpin structures by telemeric C-strand oligonucleotides

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dc.contributor.author Ahmed, Shawn
dc.contributor.author Henderson, Eric
dc.contributor.author Henderson, Eric
dc.contributor.department Zoology and Genetics
dc.date 2018-02-18T09:38:55.000
dc.date.accessioned 2020-07-07T05:16:54Z
dc.date.available 2020-07-07T05:16:54Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 1992
dc.date.issued 1992
dc.description.abstract <p>Telomeres are specialized structures at the ends of chromosomes that are required for long term chromosome stability and replication of the chromosomal terminus. Telomeric DNA consists of simple repetitive sequences with one strand G-rich relative to the other, C-rich, strand. Evolutionary conservation of this feature of telomeric repeat sequences suggests that they have specific structural characteristics involved in telomere function. Absorbance thermal denaturation, chemical modification and non-denaturing gel electrophoretic analyses showed that telomeric C-strand oligonucIeotides form stable non-Watson-Crick hairpin structures containing C.C + base pairs.Formation of such hairpins may facilitate previously reported G-strand exclusive interactions.</p>
dc.description.comments <p>This article is from <em>Nucleic Acids Research </em>20 (1992): 507, doi: <a href="https://doi.org/10.1093/nar/20.3.507">10.1093/nar/20.3.507</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/zool_pubs/32/
dc.identifier.articleid 1021
dc.identifier.contextkey 10112930
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath zool_pubs/32
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92642
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/zool_pubs/32/1992_Henderson_FormationNovel.pdf|||Fri Jan 14 23:34:15 UTC 2022
dc.source.uri 10.1093/nar/20.3.507
dc.subject.disciplines Cell and Developmental Biology
dc.subject.disciplines Genetics
dc.subject.disciplines Genomics
dc.subject.disciplines Molecular Genetics
dc.title Formation of novel hairpin structures by telemeric C-strand oligonucleotides
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 68bc511a-afd6-4353-ae20-066de33682b9
relation.isOrgUnitOfPublication 4a2929da-5374-4338-b62f-f5fd9e156ef9
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