Characterization of the LITAF-like gene family in Anopheles gambiae and its possible role in mosquito antimalarial immunity

dc.contributor.author Guinness, Andrew
dc.contributor.department Entomology
dc.date 2018-02-18T16:33:13.000
dc.date.accessioned 2020-07-07T05:11:36Z
dc.date.available 2020-07-07T05:11:36Z
dc.date.issued 2017-04-11
dc.description.abstract <p>Malaria is a dangerous and sometimes fatal parasitic disease transmitted to humans through the bite of infected female mosquitoes. Only a few species of mosquitoes are capable of transmitting malaria parasites, the most prominent of which being Anopheles gambiae, due in part to the actions of the mosquito innate immune system. To better understand the contributions of innate immunity system on malaria parasite development in the mosquito host, our research has focused on the characterization of a highly conserved LPSinduced TNF-α factor (LITAF)-like gene family in An. gambiae. Previous experiments have demonstrated that LITAF-like 3, or LL3, is an important transcription factor required for immune cell differentiation and is a key determinant of parasite survival. Here we explore the regulation and the respective contributions of the other six LITAF-like genes in An. gambiae to malaria parasite development. Mosquito immunity to parasites may prove a vital translational tool in preventing transmission.</p>
dc.identifier archive/lib.dr.iastate.edu/undergradresearch_symposium/2017/presentations/11/
dc.identifier.articleid 1191
dc.identifier.contextkey 10452194
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath undergradresearch_symposium/2017/presentations/11
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91775
dc.source.bitstream archive/lib.dr.iastate.edu/undergradresearch_symposium/2017/presentations/11/I.C_Guinness.pptx|||Fri Jan 14 18:37:41 UTC 2022
dc.subject.disciplines Entomology
dc.subject.disciplines Genetics
dc.title Characterization of the LITAF-like gene family in Anopheles gambiae and its possible role in mosquito antimalarial immunity
dc.type event
dc.type.genre event
dspace.entity.type Publication
relation.isOrgUnitOfPublication f47c8cad-50be-4fb0-8870-902ff536748c
thesis.degree.discipline Biology
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