Two clinical isolates of Mycoplasma hyosynoviae showed differing pattern of lameness and pathogen detection in experimentally challenged pigs

Date
2016-12-01
Authors
Gomes-Neto, João
Raymond, Matthew
Bower, Leslie
Ramirez, Alejandro
Madson, Darin
Strait, Erin
Rosey, Everett
Rapp-Gabrielson, Vicki
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Abstract

Mycoplasma (M.) hyosynoviae is known to colonize and cause disease in growing-finishing pigs. In this study, two clinical isolates of M. hyosynoviae were compared by inoculating cesarean-derived colostrum-deprived and specific-pathogen-free growing pigs. After intranasal or intravenous inoculation, the proportion and distribution pattern of clinical cases was compared in addition to the severity of lameness. Tonsils were found to be the primary site of colonization, while bacteremia was rarely detected prior to the observation of clinical signs. Regardless of the clinical isolate, route of inoculation, or volume of inocula, histopathological alterations and tissue invasion were detected in multiple joints, indicating an apparent lack of specific joint tropism. Acute disease was primarily observed 7 to 10 days post-inoculation. The variability in the severity of synovial microscopic lesions and pathogen detection in joint cavities suggests that the duration of joint infection may influence the diagnostic accuracy. In summary, these findings demonstrate that diagnosis of M. hyosynoviae-associated arthritis can be influenced by the clinical isolate, and provides a study platform to investigate the colonization and virulence potential of field isolates. This approach can be particularly relevant to auxiliate in surveillance and testing of therapeutic and/or vaccine candidates.

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This article is published as Gomes-Neto, João Carlos, Matthew Raymond, Leslie Bower, Alejandro Ramirez, Darin M. Madson, Erin L. Strait, Everett L. Rosey, and Vicki J. Rapp-Gabrielson. "Two clinical isolates of Mycoplasma hyosynoviae showed differing pattern of lameness and pathogen detection in experimentally challenged pigs." Journal of Veterinary Science 17, no. 4 (2016): 489-496. DOI: 10.4142/jvs.2016.17.4.489. Posted with permission.

Keywords
Mycoplasma hyosynoviae, arthritis, lameness, swine
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