β-agonist Regulate Skeletal Actin Gene Expression Post-transcriptionally

dc.contributor.author Reecy, James
dc.contributor.author Reecy, James
dc.contributor.author Morris, David
dc.date 2018-08-25T18:43:28.000
dc.date.accessioned 2020-06-29T23:28:11Z
dc.date.available 2020-06-29T23:28:11Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2004
dc.date.issued 2004-01-01
dc.description.abstract <p>Previously reported studies have provided evidence that ractopamine regulates the expression of skeletal α- actin, but the molecular mechanisms underlying these effects are poorly understood. This was the first study to look specifically at the effects of ractopamine on the transcriptional regulation of a contractile protein in myotube cultures. Our model was sufficient to evaluate the anabolic effects of ractopamine in porcine skeletal muscle. However, we were unable to identify a cis-acting DNA element within the cloned porcine skeletal α-actin promoter that conferred transcriptional responsiveness to ractopamine in porcine skeletal muscle. Thus, it appears that ractopamine promotes the accumulation of skeletal α- actin mRNA in porcine skeletal muscle via a posttranscriptional mechanism. Elucidation of the mechanism whereby ractopamine increase skeletal muscle growth will aid in the development of new strategies, both genetic and pharmacological, to improve lean tissue deposition in livestock species.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol650/iss1/107/
dc.identifier.articleid 1107
dc.identifier.contextkey 3310998
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-616
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol650/iss1/107
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/8075
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol650/iss1/107/AS1948.pdf|||Fri Jan 14 18:26:06 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R1948
dc.title β-agonist Regulate Skeletal Actin Gene Expression Post-transcriptionally
dc.type article
dc.type.genre swine
dspace.entity.type Publication
relation.isAuthorOfPublication fb994cd9-94d5-4370-94ab-f33934c4cd6f
relation.isJournalIssueOfPublication 3f2790ae-9c11-4703-87e0-39b318362bbc
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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