Alternative Ac/Ds transposition induces major chromosomal rearrangements in maize

Thumbnail Image
Date
2009-01-01
Authors
Zhang, Jianbo
Yu, Chuanhe
Pulletikurti, Vinay
Lamb, Jonathan
Danilova, Tatiana
Weber, Daniel
Birchler, James
Peterson, Thomas
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Person
Peterson, Thomas
Professor Emeritus
Research Projects
Organizational Units
Organizational Unit
Organizational Unit
Journal Issue
Is Version Of
Versions
Series
Department
AgronomyGenetics, Development and Cell Biology
Abstract

Barbara McClintock reported that the Ac/Ds transposable element system can generate major chromosomal rearrangements (MCRs), but the underlying mechanism has not been determined. Here, we identified a series of chromosome rearrangements derived from maize lines containing pairs of closely linked Ac transposable element termini. Molecular and cytogenetic analyses showed that the MCRs in these lines comprised 17 reciprocal translocations and two large inversions. The breakpoints of all 19 MCRs are delineated by Ac termini and characteristic 8-base-pair target site duplications, indicating that the MCRs were generated by precise transposition reactions involving the Ac termini of two closely linked elements. This alternative transposition mechanism may have contributed to chromosome evolution and may also occur during V(D)J recombination resulting in oncogenic translocations.

Comments

This article is from Genes & Development 23 (2009): 755, doi: 10.1101/gad.1776909. Posted with permission.

Description
Keywords
Citation
DOI
Copyright
Thu Jan 01 00:00:00 UTC 2009
Collections