Effect of Dietary Soy Genistein on Pig Growth and Immune Response during a Viral Challenge

dc.contributor.author Greiner, L.
dc.contributor.author Stahly, T.
dc.contributor.author Stabel, T.
dc.date 2018-02-12T23:57:04.000
dc.date.accessioned 2020-07-02T07:01:15Z
dc.date.available 2020-07-02T07:01:15Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2001
dc.date.embargo 2012-08-13
dc.date.issued 2001-01-01
dc.description.abstract <p>Twelve replications of four littermate pigs from a herd naive for porcine reproductive and respiratory syndrome (PRRS) were weaned (10 ± 2 d of age) and penned individually in disease isolation rooms. Pigs were randomly allotted within litter to one of four dietary concentrations of soy genistein (0, 200, 400, 800 ppm) to quantify the effect of genistein on growth and immune response during a viral challenge. Genistein was provided as the soy glycoside, genistin. At 29 ± 2 d of age (4.9 ± 1.4 kg BW), pigs were oronasally inoculated with 10<sup>4.3</sup> PRRS virus/mL from strain JA142 in a 2-mL dose. Blood was collected every 4 d from d 0 to 24 postinoculation (PI) and analyzed for serum PPRS virus, interferon (IFN) activity, and alpha-1-acylglycoprotein (AGP) concentrations. Serum virus and IFN peaked at 10<sup>5</sup> virus/mL and 57% protection, respectively, at 4 d PI and then declined steadily. Serum AGP concentration peaked at 12 d PI. As dietary genistein concentration increased, serum concentrations of PRRS virus decreased linearly (10<sup>2.46</sup>, 10<sup>2.26</sup>, 10<sup>2.05</sup>, 10<sup>2.14</sup> virus per mL of serum, <em>P</em> < .07) and IFN responded quadratically (28.4, 25.7, 22.8, 30.9% protection, <em>P</em> < .06) independent of d PI. AGP concentrations increased (<em>P</em> < .01) quadratically with the magnitude of the response to dietary genistein maximized at 12 to 16 d PI. Effects of dietary genistein on daily pig gain and feed intake were dependent on dietary genistein concentration and stage of viremia. Daily pig gains from d 0 to 24 postinoculation were improved quadratically (243, 281, 250, 246 g, P < .07) as dietary genistein increased, but the magnitude of the response to dietary genistein concentration lessened as the serum virus concentrations were minimized. Daily feed intakes also were improved quadratically (315, 371, 345, 317 g, <em>P</em> < .05) as genistein concentration increased. These data indicate that dietary soy genistein at 200 to 400 ppm is an orally active immune modulator that enhances systemic serum virus elimination and body growth in virally challenged pigs.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/swinereports_2000/5/
dc.identifier.articleid 1010
dc.identifier.contextkey 3209805
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath swinereports_2000/5
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91273
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R654
dc.source.bitstream archive/lib.dr.iastate.edu/swinereports_2000/5/asl_654.pdf|||Sat Jan 15 00:31:15 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R654
dc.title Effect of Dietary Soy Genistein on Pig Growth and Immune Response during a Viral Challenge
dc.type article
dc.type.genre nutrition
dspace.entity.type Publication
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
48.25 KB
Adobe Portable Document Format