Building Synthetic Yeast Factories to Produce Fat-soluble Antioxidants

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Zhao, Yuxin
Yao, Zhanyi
Desai, Vedika
Chen, Dan
Major Professor
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Elsevier Ltd
Shao, Zengyi
Associate Professor
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Chemical and Biological Engineering

The function of the Department of Chemical and Biological Engineering has been to prepare students for the study and application of chemistry in industry. This focus has included preparation for employment in various industries as well as the development, design, and operation of equipment and processes within industry.Through the CBE Department, Iowa State University is nationally recognized for its initiatives in bioinformatics, biomaterials, bioproducts, metabolic/tissue engineering, multiphase computational fluid dynamics, advanced polymeric materials and nanostructured materials.

The Department of Chemical Engineering was founded in 1913 under the Department of Physics and Illuminating Engineering. From 1915 to 1931 it was jointly administered by the Divisions of Industrial Science and Engineering, and from 1931 onward it has been under the Division/College of Engineering. In 1928 it merged with Mining Engineering, and from 1973–1979 it merged with Nuclear Engineering. It became Chemical and Biological Engineering in 2005.

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1913 - present

Historical Names

  • Department of Chemical Engineering (1913–1928)
  • Department of Chemical and Mining Engineering (1928–1957)
  • Department of Chemical Engineering (1957–1973, 1979–2005)
    • Department of Chemical and Biological Engineering (2005–present)

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Microbiology allows you to learn about the microorganisms that affect us every day and how they interact with their surroundings. Through the program, you will be equipped with the knowledge to work in areas related to agriculture, the environment and medicine.
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Bioeconomy Institute
The Bioeconomy Institute at Iowa State University leads the nation and world in establishing the bioeconomy, where society obtains renewable fuel, energy, chemicals, and materials from agricultural sources. The institute seeks to advance the use of biorenewable resources for the production of fuels, energy, chemicals, and materials. The Institute will assure Iowa’s prominence in the revolution that is changing the way society obtains its essential sources of energy and carbon. This revolution will dramatically reduce our dependence on petroleum. Instead of fossil sources of carbon and energy, the bioeconomy will use biomass (including lignocellulose, starches, oils and proteins) as a renewable resource to sustain economic growth and prosperity. Agriculture will supply renewable energy and carbon to the bioeconomy while engineering will transform these resources into transportation fuels, commodity chemicals, and electric power. This transformation, however, must be done in a manner that meets our present needs without compromising those of future generations.
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Ames National Laboratory

Ames National Laboratory is a government-owned, contractor-operated national laboratory of the U.S. Department of Energy (DOE), operated by and located on the campus of Iowa State University in Ames, Iowa.

For more than 70 years, the Ames National Laboratory has successfully partnered with Iowa State University, and is unique among the 17 DOE laboratories in that it is physically located on the campus of a major research university. Many of the scientists and administrators at the Laboratory also hold faculty positions at the University and the Laboratory has access to both undergraduate and graduate student talent.

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Fat-soluble antioxidants play a vital role in protecting the body against oxidative stress and damage. The rapid advancements in metabolic engineering and synthetic biology have offered a promising avenue for economically producing fat-soluble antioxidants by engineering microbial chassis. This review provides an overview of the recent progress in engineering yeast microbial factories to produce three main groups of lipophilic antioxidants: carotenoids, vitamin E, and stilbenoids. In addition to discussing the classic strategies employed to improve precursor availability and alleviate carbon flux competition, this review delves deeper into the innovative approaches focusing on enzyme engineering, product sequestration, subcellular compartmentalization, multistage fermentation, and morphology engineering. We conclude the review by highlighting the prospects of microbial engineering for lipophilic antioxidant production.
This is a manuscript of the article Published as Zhao, Yuxin, Zhanyi Yao, Vedika Desai, Dan Chen, and Zengyi Shao. "Building Synthetic Yeast Factories to Produce Fat-soluble Antioxidants." Current Opinion in Biotechnology 87 (2024): 103129. doi: Posted with Permission.