Association of Serum Antibody Levels Following Vaccination with A Modified Live BVDV Vaccine and Protection from Clinical Disease upon Challenge

dc.contributor.author Falkenberg, Shollie
dc.contributor.author Ridpath, Julia
dc.contributor.author Reecy, James
dc.contributor.author Tait, Richard
dc.contributor.author Vander Ley, Brian
dc.contributor.author Bauermann, Fernando
dc.contributor.author Reecy, James
dc.contributor.department Animal Science
dc.date 2018-02-17T04:20:29.000
dc.date.accessioned 2020-06-29T23:38:39Z
dc.date.available 2020-06-29T23:38:39Z
dc.date.issued 2015-03-01
dc.description.abstract <p>Two studies were conducted to examine the range of virus neutralizing serum antibody (VNSA) response after vaccination with a modified-live viral vaccine in cattle and the level of protection elicited when subsequently challenged with a highly virulent type 2 BVDV. Study 1 examined responses in colostrum deprived (CD) calves with no passively acquired antibodies whereas Study 2 examined responses in conventionally raised (CR) calves which had varying levels of passive antibodies prior to vaccination. Study 1 used CD calves averaging 120 days of age. For Study 2, calves averaged 130 days of age and were stratified into CR-Low, Mid and High response groups based response to vaccination. Grouping was based on standard deviations from the mean value obtained from ELISA assay and reconfirmed by virus neutralization. Twelve calves, from each Rep in Study 2, were selected to represent low, mid and high response groups (n = 4 calves per group). The VNSA values for the three groups were as follows; CR-Low (titer < 1:4), CR-Mid (titer 1:4 to 1:16) and CR-High (titer > 1:16). Calves were challenged with a high virulence BVDV2 strain. Samples were collected for both studies on days -2, 2, 4, 6, 9, 11 and 13 post challenge to determine levels of circulating white blood cells, virus isolation and levels of BVDV VNSA. While, overt respiratory or enteric disease was not observed in any of the vaccinated calves, clinical symptoms were more likely to be observed in calves with lower BVDV VNSA levels following the BVDV challenge demonstrating significant association between VNSA levels and clinical protection. However, the extent of clinical symptoms including decreases in WBC and pyrexia, were more severe in the non-vaccinated animals which indicates vaccination did provide a level of protection.</p>
dc.description.comments <p>This article is from <em>Jacob Journal of Vaccines and Vaccination</em> 1 (2015): 002.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/161/
dc.identifier.articleid 1167
dc.identifier.contextkey 7770794
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/161
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9562
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/161/2015_Reecy_AssociationSerum.pdf|||Fri Jan 14 20:55:02 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords Bovine Viral Diarrhea Virus; Vaccination; Serology
dc.title Association of Serum Antibody Levels Following Vaccination with A Modified Live BVDV Vaccine and Protection from Clinical Disease upon Challenge
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication fb994cd9-94d5-4370-94ab-f33934c4cd6f
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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