Designing Asymmetrically Modified Nanochannel Sensors Using Virtual EIS

dc.contributor.author Shrotriya, Pranav
dc.contributor.author Devarakonda, Sivaranjani
dc.contributor.author Kim, Sungu
dc.contributor.author Ganapathysubramanian, Baskar
dc.contributor.author Shrotriya, Pranav
dc.contributor.author Ganapathysubramanian, Baskar
dc.contributor.department Mechanical Engineering
dc.contributor.department Electrical and Computer Engineering
dc.contributor.department Plant Sciences Institute
dc.date 2021-06-09T19:38:21.000
dc.date.accessioned 2021-08-14T19:12:06Z
dc.date.available 2021-08-14T19:12:06Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2021
dc.date.issued 2021-01-01
dc.description.abstract <p>Monitoring electrochemical impedance changes across an asymmetrically functionalized nanochannel array provides an attractive mechanism for chemical and biological sensors. Specific binding of the receptor molecules with their analyte leads to changes in charge distribution on the nanochannel surfaces modifying the ionic transport across them. The magnitude of impedance change due to receptor/ligand binding or sensor sensitivity depends on a large number of parameters and consequently, identification of parameters that result in sensitive and specific sensing performance is extremely tedious and cost-intensive. We rely on a ’virtual EIS’ procedure that models the transient ionic current due to a step-change in voltage to determine the frequency dependent impedance of an asymmetrically functionalized nanochannel. This procedure is used to predict the impedance changes due to the specific binding of thrombin on nanochannel surfaces. Surface charge changes associated with the binding of thrombin protein on the aptamer coated surface result in a decrease of the membrane impedance and computational results suggest that a reduction in the ionic strength of the electrolyte leads to an increase in the magnitude of binding induced impedance reduction. Sensing experiments with thrombin binding aptamer are performed to evaluate the trends from the high-throughput computations. The agreement between model predictions and experimental observations suggests that the present modeling approach may be utilized to computationally evaluate sensor performance for a range of parameters and rapidly identify sensor configurations that enable point-of-care diagnostic devices with improved sensitivities.</p>
dc.description.comments <p>This is a pre-print of the article Devarakonda, Sivaranjani, Sungu Kim, Baskar Ganapathysubramanian, and Pranav Shrotriya. "Designing Asymmetrically Modified Nanochannel Sensors Using Virtual EIS." (2021). DOI: <a href="https://doi.org/10.26434/chemrxiv.14714895.v1" target="_blank">10.26434/chemrxiv.14714895.v1</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/me_pubs/484/
dc.identifier.articleid 1486
dc.identifier.contextkey 23278694
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath me_pubs/484
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/7wbOPnRv
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/me_pubs/484/2021_ShrotriyaPranav_DesigningAsymmetrically.pdf|||Sat Jan 15 00:28:12 UTC 2022
dc.source.uri 10.26434/chemrxiv.14714895.v1
dc.subject.disciplines Electro-Mechanical Systems
dc.subject.disciplines Nanotechnology Fabrication
dc.subject.disciplines Systems and Communications
dc.subject.disciplines Transport Phenomena
dc.subject.keywords Nanoporous alumina
dc.subject.keywords surface charge
dc.subject.keywords virtual electrochemical impedance spectroscopy (EIS)
dc.subject.keywords thrombin
dc.title Designing Asymmetrically Modified Nanochannel Sensors Using Virtual EIS
dc.type article
dc.type.genre article
dspace.entity.type Publication
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