Comparison of oral non-steroidal anti-inflammatory drugs in cautery dehorned calves

dc.contributor.advisor Johann F. Coetzee
dc.contributor.author Stock, Matthew
dc.contributor.department Biomedical Sciences
dc.date 2018-08-11T17:29:41.000
dc.date.accessioned 2020-06-30T02:58:48Z
dc.date.available 2020-06-30T02:58:48Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.embargo 2001-01-01
dc.date.issued 2015-01-01
dc.description.abstract <p>Dehorning is a commonly performed husbandry procedure in cattle to limit injury and conform to modern facility design. Prior research provides evidence that dehorning results in increased nociception and stress through changes in behavioral, neuroendocrine, and physiological responses. Alterations in these actions allow investigators to evaluate pain and stress reducing practices. In addition to improved welfare strategies including institution of polled breeding programs and conducting the procedure on young animals, calves may benefit from the administration of analgesics including local anesthetics, non-steroidal anti-inflammatory drugs (NSAIDs), and α2-agonists. Reviews of the literature have indicated a multimodal approach including local anesthetics and NSAIDs may be the optimal strategy to mitigate the negative response following dehorning. Since no analgesic products are currently labeled for cattle in the United States, providing an appropriate and effective analgesic remains challenging. As such, we have studied the pharmacokinetics and clinical efficacy of different NSAIDs in calves undergoing cautery dehorning. Initially, we evaluated the pharmacokinetics and clinical efficacy of firocoxib following cautery dehorning in calves. Although this NSAID was well absorbed orally in calves and inhibited prostaglandin for 48 h compared to placebo treated controls, minimal analgesic effects were observed using a study dose of 0.5 mg/kg. Subsequently we evaluated the pharmacokinetics and clinical efficacy of carprofen in a similar cautery dehorning study. Using the approved anti-inflammatory dose of 1.4 mg/kg in the European Union, oral carprofen was well absorbed and moderately inhibited prostaglandin for up to 96 h, however minimal analgesic effects were observed. Following descriptions of the pharmacokinetics and effects of oral carprofen and firocoxib, a comparison of four NSAIDs (carprofen, flunixin meglumine, firocoxib, and meloxicam) orally administered at 2.0 mg/kg was conducted as a field trial. Although responses indicative of pain and stress reduction varied among the treatment groups, evidence from the field trial indicate meloxicam may have superior potency compared to the other evaluated NSAIDs. Moreover, the use of oral meloxicam provides optimal analgesia for 24 h following a one-time dose of 2.0 mg/kg.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/14735/
dc.identifier.articleid 5742
dc.identifier.contextkey 8077667
dc.identifier.doi https://doi.org/10.31274/etd-180810-4285
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/14735
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/28920
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/14735/Stock_iastate_0097E_15149.pdf|||Fri Jan 14 20:25:38 UTC 2022
dc.subject.disciplines Pharmacology
dc.subject.disciplines Veterinary Medicine
dc.subject.keywords Biomedical Sciences (Pharmacology)
dc.subject.keywords Biomedical Sciences
dc.subject.keywords Pharmacology
dc.subject.keywords Animal welfare
dc.subject.keywords Dehorning
dc.subject.keywords Nonsteroidal anti-inflammatory drugs
dc.subject.keywords Pain
dc.subject.keywords Pharmacokinetics
dc.title Comparison of oral non-steroidal anti-inflammatory drugs in cautery dehorned calves
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
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