Survey of Canine Monogenetic Diseases with Established Molecular Bases

dc.contributor.author Pepin, Brent
dc.contributor.author Hau, Samantha
dc.contributor.author Bradley, Erin
dc.contributor.author Thompson, Janessa
dc.contributor.author Brewer, Matt
dc.contributor.author Helms, Timothy
dc.contributor.author Johnson, Amie
dc.contributor.author Rotolo, Marisa
dc.contributor.author Uriell, Miranda
dc.contributor.author Brewer, Matthew
dc.contributor.author Carlson, Steve
dc.contributor.department Biomedical Sciences
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-02-18T07:49:21.000
dc.date.accessioned 2020-06-30T00:53:11Z
dc.date.available 2020-06-30T00:53:11Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2014
dc.date.issued 2014-09-11
dc.description.abstract <p>The development of a dog breed often involves selection, which intentionally propagates valued genetic traits. Unfortunately, untoward traits can be collaterally propagated during this process. For the purpose of identifying trends in canine genetic diseases, we examined 36 randomly chosen canine pathologies involving single gene mutations. For each disease we provide a brief summary of breed predilection, clinical signs, the underlying genetic mutation, and the availability of a commercial diagnostic test. The following trends were noted in this non-exhaustive list of diseases. First, these genetic diseases primarily involve the ophthalmic (28%) and nervous systems (28%). Second, no single breed was over-represented in these genetic diseases. Third, the majority (89%) of the mutations involve coding regions of the respective genes. Fourth, most (78%) mutations were autosomal recessive. Fifth, nucleotide substitutions were the most common mutation (42%). Finally, genetic testing is available for 89% of these diseases. This review encapsulates canine pathologies associated with single genetic defects, thus providing a resource for practitioners and researchers.</p>
dc.description.comments <p>This article is from Austin J Vet Sci & Anim Husb. 2014;1(1): 7. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/bms_pubs/28/
dc.identifier.articleid 1027
dc.identifier.contextkey 9951243
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bms_pubs/28
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/11151
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/bms_pubs/28/2014_Pepin_SurveyCanine.pdf|||Fri Jan 14 23:09:28 UTC 2022
dc.subject.disciplines Animal Diseases
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Survey of Canine Monogenetic Diseases with Established Molecular Bases
dc.type article
dc.type.genre article
dspace.entity.type Publication
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