Harness Organoid Models for Virological Studies in Animals: A Cross-Species Perspective

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2021-09-16
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Sang, Yongming
Miller, Laura C.
Nelli, Rahul
Giménez-Lirola, Luis
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Frontiers Media S.A.
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Giménez-Lirola, Luis
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Veterinary Diagnostic and Production Animal Medicine
Abstract
Animal models and cell culture in vitro are primarily used in virus and antiviral immune research. Whereas the limitation of these models to recapitulate the viral pathogenesis in humans has been made well aware, it is imperative to introduce more efficient systems to validate emerging viruses in both domestic and wild animals. Organoids ascribe to representative miniatures of organs (i.e., mini-organs), which are derived from three-dimensional culture of stem cells under respective differential conditions mimicking endogenous organogenetic niches. Organoids have broadened virological studies in the human context, particularly in recent uses for COVID19 research. This review examines the status and potential for cross-species applied organotypic culture in validating emerging animal, particularly zoonotic, viruses in domestic and wild animals.
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This article is published as Sang, Yongming, Laura C. Miller, Rahul K. Nelli, and Luis Gabriel Giménez-Lirola. "Harness Organoid Models for Virological Studies in Animals: A Cross-Species Perspective." Frontiers in Microbiology (2021): 2738. DOI: 10.3389/fmicb.2021.725074. Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
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