Unidirectional, electrotactic-response valve for Caenorhabditis elegans in microfluidic devices

Date
2011-04-04
Authors
Carr, John A.
Lycke, Roy
Parashar, Archana
Pandey, Santosh
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AIP Publishing LLC
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Electrical and Computer Engineering
Abstract
We report a nematode electrotactic-response valve (NERV) to control the locomotion of Caenorhabditis elegans (C. elegans) in microfluidic devices. This nonmechanical, unidirectional valve is based on creating a confined region of lateral electric field that is switchable and reversible. We observed that C. elegans do not prefer to pass through this region if the field lines are incident to its forward movement. Upon reaching the boundary of the NERV, the incident worms partially penetrate the field region, pull back, and turn around. The NERV is tested on three C. elegans mutants: wild-type (N2), lev-8, and acr-16.
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This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Carr, John A., Roy Lycke, Archana Parashar, and Santosh Pandey. "Unidirectional, electrotactic-response valve for Caenorhabditis elegans in microfluidic devices." Applied Physics Letters 98, no. 14 (2011): 143701, and may be found at DOI: 10.1063/1.3570629. Copyright 2011 American Institute of Physics. Posted with permission.
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