A Homologous Bacterin Protects Sheep against Abortion Induced by a Hypervirulent Campylobacter jejuni Clone

Date
2020-11-06
Authors
Plummer, Paul
Wu, Zuowei
Yaeger, Michael
Sahin, Orhan
Zhang, Qijing
Xu, Changyun
Beyi, Ashenafi
Plummer, Paul
Ocal, Melda
Zhang, Qijing
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Veterinary PathologyVeterinary Microbiology and Preventive MedicineVeterinary Diagnostic and Production Animal Medicine
Abstract

Campylobacter jejuni clone SA has emerged as the predominant cause of ovine abortion outbreaks in the United States (US). Despite the fact that commercial Campylobacter vaccines are available, their efficacy in protecting abortion induced by C. jejuni clone SA is uncertain, and a protective vaccine is needed to control the disease. In this study, an experimental homologous bacterin (made of a clone SA isolate) and two commercial Campylobacter vaccines were evaluated for their protection against C. jejuni clone SA-induced sheep abortion. All vaccines induced high levels of antibodies against C. jejuni clone SA in pregnant ewes, but only the experimental homologous bacterin produced significant protection (80%). Immunoblotting showed that the experimental vaccine elicited more specific antibodies against C. jejuni clone SA. These findings strongly suggest the necessity of developing a homologous vaccine for the control C. jejuni clone SA induced abortion on sheep farms

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This article is published as Wu, Zuowei, Michael J. Yaeger, Orhan Sahin, Changyun Xu, Ashenafi F. Beyi, Paul J. Plummer, Melda Meral Ocal, and Qijing Zhang. "A Homologous Bacterin Protects Sheep against Abortion Induced by a Hypervirulent Campylobacter jejuni Clone." Vaccines 8, no. 4 (2020): 662. DOI: 10.3390/vaccines8040662. Posted with permission.

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