Placement of Prolactin on Pig Chromosome 7 by Linkage and Physical Mapping

Abstract

<p>The study of genes which code for functional protein products have important implications in comparative genetic mapping and perhaps to the swine industry. The identification of a polymorphism, or change at the DNA level, is used to assign these genes to their corresponding chromosomes by the statistical method of two-point linkage analysis. A polymorphism was detected in the Prolactin gene (PRL) and was used to linkage map PRL to pig chromosome 7. To confirm this location, PRL also was genetically physically mapped using a pig x rodent somatic cell hybrid panel. These results confirm that the short arm of pig 7 contains another of the genes on human chromosome 6.</p>