Consequences of immune system aging in nature: a study of immunosenescence costs in free-living Tree Swallows

dc.contributor.author Palacios, Maria
dc.contributor.author Winkler, David
dc.contributor.author Vleck, Carol
dc.contributor.author Klasing, Kirk
dc.contributor.author Hasselquist, Dennis
dc.contributor.author Vleck, Carol
dc.contributor.department Ecology, Evolution and Organismal Biology
dc.date 2018-02-17T17:11:51.000
dc.date.accessioned 2020-06-30T02:19:20Z
dc.date.available 2020-06-30T02:19:20Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2011
dc.date.issued 2011-04-01
dc.description.abstract <p>Immunosenescence, the aging of the immune system, is well documented in humans and laboratory models and is known to increase infection risk, morbidity, and mortality among the old. Immunosenescence patterns have recently been unveiled in various free-living populations, but their consequences in the wild have not been explored. We investigated the consequences of immunosenescence in free-living Tree Swallows <em>Tachycineta bicolor</em>through a field experiment simulating a bacterial infection (challenge with lipopolysaccharide, LPS) in females of different ages during the nestling rearing period. We assessed behavioral and physiological responses of females, as well as growth and quality of their offspring, to determine the costs associated with the simulated infection. Results of the experiment differed between the two years of study. In the first year, old females challenged with LPS lost more body mass and reduced their nest visitation rates more, and their offspring tended to grow slower compared to similarly challenged younger females. In contrast, in the second year, old females did not appear to suffer larger costs than younger ones. Interestingly, immunosenescence was only detected during the first year of the study, suggesting that it is the dysregulated immune function characteristic of immunosenescent individuals rather than age per se that can lead to higher costs of immune defense in old individuals. These results provide the first evidence of costs of immunosenescence in free-living animals and support the hypothesis that old, immunosenescent individuals pay higher costs than younger ones when faced with a challenge to their immune system. Our results also suggest that these costs are mediated by an exaggerated sickness behavior, as seen in laboratory models, and can be modulated by ecological factors such as weather conditions and food availability.</p>
dc.description.comments <p>This article is from <em>Ecology </em>92 (2011): 952, doi: <a href="http://dx.doi.org/10.1890/10-0662.1" target="_blank">10.1890/10-0662.1</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/eeob_las_pubs/5/
dc.identifier.articleid 1004
dc.identifier.contextkey 8591647
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath eeob_las_pubs/5
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/23371
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/eeob_las_pubs/5/2011_Vleck_ConsequencesImmune.pdf|||Sat Jan 15 00:34:56 UTC 2022
dc.source.uri 10.1890/10-0662.1
dc.subject.disciplines Ornithology
dc.subject.disciplines Other Ecology and Evolutionary Biology
dc.subject.disciplines Terrestrial and Aquatic Ecology
dc.subject.disciplines Zoology
dc.subject.keywords acute phase response
dc.subject.keywords bacterial killing
dc.subject.keywords disease
dc.subject.keywords ecological immunology
dc.subject.keywords immunocompetence
dc.subject.keywords lipopolysaccharide
dc.subject.keywords lysozyme
dc.subject.keywords senescence
dc.subject.keywords sickness behavior
dc.title Consequences of immune system aging in nature: a study of immunosenescence costs in free-living Tree Swallows
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 802c63cc-04db-40de-8dea-32f0b76f7197
relation.isOrgUnitOfPublication fb57c4c9-fba7-493f-a416-7091a6ecedf1
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