Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids
dc.contributor.author | Caston, Stephanie | |
dc.contributor.author | Sponseller, Brett | |
dc.contributor.author | Dembek, Katarzyna | |
dc.contributor.author | Hostetter, Jesse | |
dc.contributor.author | Caston, Stephanie | |
dc.contributor.department | Veterinary Pathology | |
dc.contributor.department | Veterinary Clinical Sciences | |
dc.contributor.department | Veterinary Microbiology and Preventive Medicine | |
dc.date | 2020-04-30T03:42:08.000 | |
dc.date.accessioned | 2020-07-07T05:12:27Z | |
dc.date.available | 2020-07-07T05:12:27Z | |
dc.date.copyright | Wed Jan 01 00:00:00 UTC 2020 | |
dc.date.issued | 2020-04-22 | |
dc.description.abstract | <p>A reformulation of <em>Mycobacterium</em> cell wall fraction immunotherapeutic can be used to successfully treat sarcoids in horses. Sarcoids are reported to be the most common equine skin tumors with tumor type and location influencing the choice of treatment. Wide surgical excision is curative for many tumors, but may not always be feasible. Previous studies have reported sarcoid regression after injection with mycobacterial cell wall immunotherapeutics. A new formulation of the <em>Mycobacterium phlei</em> cell wall fraction immunostimulant (Immunocidin® Equine) was utilized to treat cutaneous tumors in horses. Equids with skin tumors diagnosed as sarcoids were enrolled in the study. Sarcoids were injected at the initial visit with Immunocidin® Equine and subsequently at approximately 2-week intervals. Of 17 cases, 9 cases were completely resolved at the end of the study period evaluation or at time of final follow up (52.9%). Three cases were reported as improved (smaller), but not resolved (17.6%). Three cases were discontinued from the study as the respective masses were growing larger or not resolving (17.6%). One case (5.8%) with two masses had resolution of one mass, whereas the other tumor had a small regrowth 5 months after the last treatment. One case (5.8%) was lost to follow up. All cases had mild to moderate swelling of the injection site, and some cases had discharge after the second, third, or fourth injections. No serious systemic side effects or complications were encountered during the study.</p> | |
dc.description.comments | <p>This is a manuscript of an article published as Caston, Stephanie S., Brett A. Sponseller, Katarzyna A. Dembek, and Jesse M. Hostetter. "Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids." <em>Journal of Equine Veterinary Science</em> (2020): 103102. DOI: <a href="https://doi.org/10.1016/j.jevs.2020.103102" target="_blank">10.1016/j.jevs.2020.103102</a>. Posted with permission.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/vcs_pubs/45/ | |
dc.identifier.articleid | 1044 | |
dc.identifier.contextkey | 17568392 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | vcs_pubs/45 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/91925 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/vcs_pubs/45/2020_CastonStephanie_EvaluationLocally.pdf|||Sat Jan 15 00:20:32 UTC 2022 | |
dc.source.uri | 10.1016/j.jevs.2020.103102 | |
dc.subject.disciplines | Large or Food Animal and Equine Medicine | |
dc.subject.disciplines | Veterinary Infectious Diseases | |
dc.subject.disciplines | Veterinary Microbiology and Immunobiology | |
dc.title | Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 1c1bb4d0-92d3-4b12-9818-8ad2c44ee517 | |
relation.isOrgUnitOfPublication | cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f | |
relation.isOrgUnitOfPublication | 1ad68def-86ae-460b-8808-f1b1febafd0a | |
relation.isOrgUnitOfPublication | 16f8e472-b1cd-4d8f-b016-09e96dbc4d83 |
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