Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids

dc.contributor.author Caston, Stephanie
dc.contributor.author Sponseller, Brett
dc.contributor.author Dembek, Katarzyna
dc.contributor.author Hostetter, Jesse
dc.contributor.author Auck, Stephanie
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Clinical Sciences
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2020-04-30T03:42:08.000
dc.date.accessioned 2020-07-07T05:12:27Z
dc.date.available 2020-07-07T05:12:27Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.issued 2020-04-22
dc.description.abstract <p>A reformulation of <em>Mycobacterium</em> cell wall fraction immunotherapeutic can be used to successfully treat sarcoids in horses. Sarcoids are reported to be the most common equine skin tumors with tumor type and location influencing the choice of treatment. Wide surgical excision is curative for many tumors, but may not always be feasible. Previous studies have reported sarcoid regression after injection with mycobacterial cell wall immunotherapeutics. A new formulation of the <em>Mycobacterium phlei</em> cell wall fraction immunostimulant (Immunocidin® Equine) was utilized to treat cutaneous tumors in horses. Equids with skin tumors diagnosed as sarcoids were enrolled in the study. Sarcoids were injected at the initial visit with Immunocidin® Equine and subsequently at approximately 2-week intervals. Of 17 cases, 9 cases were completely resolved at the end of the study period evaluation or at time of final follow up (52.9%). Three cases were reported as improved (smaller), but not resolved (17.6%). Three cases were discontinued from the study as the respective masses were growing larger or not resolving (17.6%). One case (5.8%) with two masses had resolution of one mass, whereas the other tumor had a small regrowth 5 months after the last treatment. One case (5.8%) was lost to follow up. All cases had mild to moderate swelling of the injection site, and some cases had discharge after the second, third, or fourth injections. No serious systemic side effects or complications were encountered during the study.</p>
dc.description.comments <p>This is a manuscript of an article published as Caston, Stephanie S., Brett A. Sponseller, Katarzyna A. Dembek, and Jesse M. Hostetter. "Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids." <em>Journal of Equine Veterinary Science</em> (2020): 103102. DOI: <a href="https://doi.org/10.1016/j.jevs.2020.103102" target="_blank">10.1016/j.jevs.2020.103102</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vcs_pubs/45/
dc.identifier.articleid 1044
dc.identifier.contextkey 17568392
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vcs_pubs/45
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91925
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vcs_pubs/45/2020_CastonStephanie_EvaluationLocally.pdf|||Sat Jan 15 00:20:32 UTC 2022
dc.source.uri 10.1016/j.jevs.2020.103102
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.title Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 1c1bb4d0-92d3-4b12-9818-8ad2c44ee517
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
relation.isOrgUnitOfPublication 1ad68def-86ae-460b-8808-f1b1febafd0a
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
Original bundle
Now showing 1 - 1 of 1
4.7 MB
Adobe Portable Document Format