Quantitation of Gait and Stance Alterations Due to Monosodium Iodoacetate–induced Knee Osteoarthritis in Yucatan Swine

dc.contributor.author Karriker, Locke
dc.contributor.author LaVallee, Katherine
dc.contributor.author Maus, Timothy
dc.contributor.author Stock, Joseph
dc.contributor.author Stalder, Kenneth
dc.contributor.author Stalder, Kenneth
dc.contributor.author Karriker, Locke
dc.contributor.author Murthy, Naveen
dc.contributor.author Kanwar, Rahul
dc.contributor.author Beutler, Andreas
dc.contributor.author Unger, Mark
dc.contributor.department Animal Science
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2020-06-12T02:23:06.000
dc.date.accessioned 2020-07-07T05:13:13Z
dc.date.available 2020-07-07T05:13:13Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.issued 2020-06-01
dc.description.abstract <p>Knee osteoarthritis is one of the most common causes of chronic pain worldwide, and several animal models have been developed to investigate disease mechanisms and treatments to combat associated morbidities. Here we describe a novel method for assessment of locomotor pain behavior in Yucatan swine. We used monosodium iodoacetate (MIA) to induce osteoarthritis in the hindlimb knee, and then conducted live observation, quantitative gait analysis, and quantitative weight-bearing stance analysis. We used these methods to test the hypothesis that locomotor pain behaviors after osteoarthritis induction would be detected by multiparameter quantitation for at least 12 wk in a novel large animal model of osteoarthritis. MIA-induced knee osteoarthritis produced lameness quantifiable by all measurement techniques, with onset at 2 to 4 wk and persistence until the conclusion of the study at 12 wk. Both live observation and gait analysis of kinetic parameters identified mild and moderate osteoarthritis phenotypes corresponding to a binary dose relationship. Quantitative stance analysis demonstrated the greatest sensitivity, discriminating between mild osteoarthritis states induced by 1.2 and 4.0 mg MIA, with stability of expression for as long as 12 wk. The multiparameter quantitation used in our study allowed rejection of the null hypothesis. This large animal model of quantitative locomotor pain resulting from MIA-induced osteoarthritis may support the assessment of new analgesic strategies for human knee osteoarthritis.</p>
dc.description.comments <p>This article is published as LaVallee, Katherine T., Timothy P. Maus, Joseph D. Stock, Kenneth J. Stalder, Locke A. Karriker, Naveen S. Murthy, Rahul Kanwar, Andreas S. Beutler, and Mark D. Unger. "Quantitation of Gait and Stance Alterations Due to Monosodium Iodoacetate–induced Knee Osteoarthritis in Yucatan Swine." <em>Comparative Medicine</em> 70, no. 3 (2020): 248–257. DOI: <a href="https://doi.org/10.30802/AALAS-CM-19-000075" target="_blank">10.30802/AALAS-CM-19-000075</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/192/
dc.identifier.articleid 1196
dc.identifier.contextkey 18069653
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/192
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92040
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/192/0-2020_KarrickerLocke_PermGrant_QuantitationGait.pdf|||Fri Jan 14 21:53:32 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/192/2020_KarrikerLocke_QuantitationGait.pdf|||Fri Jan 14 21:53:34 UTC 2022
dc.source.uri 10.30802/AALAS-CM-19-000075
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Orthopedics
dc.title Quantitation of Gait and Stance Alterations Due to Monosodium Iodoacetate–induced Knee Osteoarthritis in Yucatan Swine
dc.type article
dc.type.genre article
dspace.entity.type Publication
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