Measurement of Intraocular Pressures in Glaucomatous and Non-glaucomatous Kittens
Glaucoma, a group of eye conditions associated with damage to the retina and optic nerve, is commonly associated with increased pressure within the eye, or intraocular pressure (IOP). This project was focused on gaining an understanding of the differences in eyelid opening and IOP between affected and unaffected kittens in an inherited glaucoma feline breeding colony. IOP measurements were taken in the morning and evening within 48-hour windows for 10, 13, 17, 21, 28, 35, and 42 days postnatally by rebound tonometry of non-sedated, lightly restrained animals. Measurements were recorded in triplicates from each eye resulting in a total of six measurements for each timepoint, which were then averaged for each kitten. Genotypes for all kittens were determined by lineage analysis prior to statistical analysis of the data using a repeated measures ANOVA. In the window of time from eyelid opening to weaning, glaucomatous kittens showed significantly higher IOP measurements compared to unaffected cats of the same age. Future studies will be aimed at establishing standard IOP ranges for affected and unaffected kittens to aid in the early diagnosis and treatment of glaucoma to maintain vision in affected cats.