Three-Phase Model Harmonizes Estimates of the Maximal Suppression of Parathyroid Hormone by 25-Hydroxyvitamin D in Persons 65 Years of Age and Older

dc.contributor.author Durazo-Arvizu, Ramon
dc.contributor.author Dawson-Hughes, Bess
dc.contributor.author Carriquiry, Alicia
dc.contributor.author Sempos, Christopher
dc.contributor.author Yetley, Elizabeth
dc.contributor.author Looker, Anne
dc.contributor.author Cao, Guichan
dc.contributor.author Harris, Susan
dc.contributor.author Burt, Vicki
dc.contributor.author Carriquiry, Alicia
dc.contributor.author Picciano, Mary
dc.contributor.department Statistics
dc.date 2018-02-17T06:24:05.000
dc.date.accessioned 2020-07-02T06:57:49Z
dc.date.available 2020-07-02T06:57:49Z
dc.date.issued 2010-01-01
dc.description.abstract <p>The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status. Depending upon the definition of maximal suppression of iPTH and the 2-phase regression approach used, 2 distinct clusters for a single 25(OH)D threshold have been reported: 16-20 ng/mL (40-50 nmol/L) and 30-32 ng/mL (75-80 nmol/L). To rationalize the apparently disparate published results, we compared thresholds from several regression models including a 3-phase one to estimate simultaneously 2 thresholds before and after adjusting for possible confounding for age, BMI, glomerular filtration rate, dietary calcium, and season (April-September vs. October-March) within a single data set, i.e. data from the Tufts University Sites Testing Osteoporosis Prevention/Intervention Treatment study, consisting of 181 men and 206 women (total n = 387) ages 65-87 y. Plasma 25(OH)D and serum iPTH concentrations were (mean ± SD) 22.1 ± 7.44 ng/mL (55.25 ± 18.6 nmol/L) and 36.6 ± 16.03 pg/mL (3.88 ± 1.7 pmol/L), respectively. The 3-phase model identified 2 thresholds of 12 ng/mL (30 nmol/L) and 28 ng/mL (70 nmol/L); similar results were found from the 2-phase models evaluated, i.e. 13-20 and 27-30 ng/mL (32.5-50 and 67.5-75 nmol/L) and with previous results. Adjusting for confounding did not change the results substantially. Accordingly, the 3-phase model appears to be superior to the 2-phase approach, because it simultaneously estimates the 2 threshold clusters found from the 2-phase approaches along with estimating confidence limits. If replicated, it may be of both clinical and public health importance.</p>
dc.description.comments <p>This article is from <em>Journal of Nutrition</em> 140 (2010): 595, doi: <a href="http://dx.doi.org/10.3945/jn.109.116681" target="_blank">10.3945/jn.109.116681</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/stat_las_pubs/37/
dc.identifier.articleid 1036
dc.identifier.contextkey 7858412
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath stat_las_pubs/37
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/90634
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/stat_las_pubs/37/2010_CarriquiryAL_ThreePhaseModel.pdf|||Fri Jan 14 23:49:22 UTC 2022
dc.source.uri 10.3945/jn.109.116681
dc.subject.disciplines Biochemical Phenomena, Metabolism, and Nutrition
dc.subject.disciplines Public Health
dc.subject.disciplines Statistics and Probability
dc.subject.keywords 25 hydroxyvitamin D
dc.subject.keywords calcium
dc.subject.keywords parathyroid hormone
dc.subject.keywords body mass
dc.subject.keywords controlled study
dc.subject.keywords elderly care
dc.subject.keywords glomerulus filtration rate
dc.subject.keywords hormone determination
dc.subject.keywords mathematical model
dc.subject.keywords maximum allowable concentration
dc.title Three-Phase Model Harmonizes Estimates of the Maximal Suppression of Parathyroid Hormone by 25-Hydroxyvitamin D in Persons 65 Years of Age and Older
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 6ddd5891-2ad0-4a93-89e5-8c35c28b0de4
relation.isOrgUnitOfPublication 264904d9-9e66-4169-8e11-034e537ddbca
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