The study examined depression, anxiety, marital satisfaction in individuals from a clinical sample and individuals from a community sample. Gender was also considered in this study. Participants of this study consisted of 268 individuals; this sample was divided between a clinical and non-clinical sample from a community in the Midwest region of the United States. The study used the Brief Symptom Inventory to measure the levels of depression and anxiety, and the Dyadic Adjustment Scale to measure marital satisfaction. The hypotheses were tested using factorial analysis of variance. Overall results suggest that depression and marital satisfaction significantly impact each other and that the clinical sample significantly differs in level of depression from the non-clinical sample.