Divergent Immune Responses and Disease Outcomes in Piglets Immunized with Inactivated and Attenuated H3N2 Swine Influenza Vaccines in the Presence of Maternally-Derived Antibodies

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dc.contributor.author Sandbulte, Matthew
dc.contributor.author Platt, Ratree
dc.contributor.author Roth, James
dc.contributor.author Roth, James
dc.contributor.author Henningson, Jamie
dc.contributor.author Gibson, Kathleen
dc.contributor.author Rajão, Daniela
dc.contributor.author Loving, Crystal
dc.contributor.author Vincent, Amy
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T04:47:18.000
dc.date.accessioned 2020-07-07T05:15:25Z
dc.date.available 2020-07-07T05:15:25Z
dc.date.issued 2014-09-01
dc.description.abstract <p>Live-attenuated influenza virus (LAIV) prime-boost vaccination previously conferred protection against heterologous H3N2 swine influenza challenge, including in piglets with maternally derived antibodies (MDA). Conversely, a whole-inactivated virus (WIV) vaccine was associated with enhanced disease. This study was aimed at identifying immune correlates of cross-protection. Piglets with and without MDA received intramuscular adjuvanted WIV or intranasal LAIV, and were challenged with heterologous H3N2. WIV induced cross-reactive IgG, inhibited by MDA, and a moderate T cell response. LAIV elicited mucosal antibodies and T cells cross-reactive to the heterologous challenge strain. The presence of MDA at LAIV vaccination blocked lung and nasal antibody production, but did not interfere with T cell priming. Even without mucosal antibodies, MDA-positive LAIV vaccinates were protected, indicating a likely role for T cells. Based on the data, one LAIV dose can induce cell-mediated immunity against antigenically divergent H3N2 influenza virus despite passive antibody interference with humoral immune responses.</p>
dc.description.comments <p>This article is from <em>Virology</em> 464-465 (2014): 45, doi:<a href="http://dx.doi.org/10.1016/j.virol.2014.06.027" id="x-ddDoi" target="_blank">10.1016/j.virol.2014.06.027</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/76/
dc.identifier.articleid 1083
dc.identifier.contextkey 7793756
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/76
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92384
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/76/2014_Roth_DivergentImmune.pdf|||Sat Jan 15 01:50:48 UTC 2022
dc.source.uri 10.1016/j.virol.2014.06.027
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords Influenza A
dc.subject.keywords Maternally derived antibodies
dc.subject.keywords Live attenuated influenza virus
dc.subject.keywords Whole inactivated virus
dc.subject.keywords Heterologous immunity
dc.title Divergent Immune Responses and Disease Outcomes in Piglets Immunized with Inactivated and Attenuated H3N2 Swine Influenza Vaccines in the Presence of Maternally-Derived Antibodies
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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