Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone

dc.contributor.author Hay Kraus, Bonnie
dc.contributor.author Hay-Kraus, Bonnie
dc.contributor.department Veterinary Clinical Sciences
dc.date 2018-11-29T07:22:33.000
dc.date.accessioned 2020-07-07T05:12:21Z
dc.date.available 2020-07-07T05:12:21Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2012
dc.date.issued 2013-01-01
dc.description.abstract <p><strong>Objective</strong> The goal of this study was to evaluate the effectiveness of maropitant (Cerenia®) in preventing vomiting after premedication with hydromorphone.</p> <p><strong>Study design</strong> Randomized, blinded, prospective clinical study.</p> <p><strong>Animals </strong>Eighteen dogs ASA I/II admitted for elective orthopedic surgical procedures. The dogs were a mixed population of males and females, purebreds and mixed breeds, 1.0–10.2 years of age, weighing 3–49.5 kg.</p> <p><strong>Methods</strong> Dogs were admitted to the study if they were greater than 1 year of age, healthy and scheduled to undergo elective orthopedic surgery. Dogs were randomly selected to receive one of two treatments administered by subcutaneous injection. Group M received 1.0 mg kg−1 of maropitant, Group S received 0.1 mL kg−1 of saline 1 hour prior to anesthesia premedication. Dogs were premedicated with 0.1 mg kg−1 of hydromorphone intramuscularly. A blinded observer documented the presence of vomiting, retching and/or signs of nausea for 30 minutes after premedication.</p> <p><strong>Results</strong> All dogs in S vomited (6/9), retched (1/9) or displayed signs of nausea (2/9). None (0/9) of the dogs in M vomited, retched or displayed signs of nausea. Dogs in M had significantly fewer incidences of vomiting (<em>p</em>=0.0090), vomiting and retching (<em>p</em>=0.0023) and vomiting, retching and nausea (<em>p</em><0.0001) when compared to S.</p> <p><strong>Conclusion and clinical relevance</strong> Maropitant prevents vomiting, retching and nausea associated with intramuscular hydromorphone administration in dogs.</p>
dc.description.comments <p>This is the peer-reviewed version of the following article: Kraus, Bonnie L. Hay. "Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone." <em>Veterinary Anaesthesia and Analgesia</em> 40, no. 1 (2013): 28-34, which has been published in final form at DOI: <a href="https://dx.doi.org/10.1111/j.1467-2995.2012.00788.x" target="_blank">10.1111/j.1467-2995.2012.00788.x</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vcs_pubs/29/
dc.identifier.articleid 1029
dc.identifier.contextkey 13380995
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vcs_pubs/29
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91907
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vcs_pubs/29/2013_Kraus_EfficacyMaropitant.pdf|||Fri Jan 14 23:13:54 UTC 2022
dc.source.uri 10.1111/j.1467-2995.2012.00788.x
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Toxicology and Pharmacology
dc.subject.keywords dogs
dc.subject.keywords hydromorphone
dc.subject.keywords maropitant
dc.subject.keywords vomiting
dc.title Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 3343acad-e989-4c4c-8ede-0760fd024b42
relation.isOrgUnitOfPublication 1ad68def-86ae-460b-8808-f1b1febafd0a
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